44(P-5) 海産ポリエーテル化合物イエッソトキシンの生合成研究(ポスター発表の部)

概要

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Yessotoxin (YTX) is a disulfated polyether toxin first isolated from scallops in Japan and its structure including the absolute configuration was elucidated. The existence of YTX in mussels outside Japan was reported from Norway, Chile, New Zealand, and Italy. Therefore, contaminations of YTX and its analogs in shellfish spreaded in worldwide, and gave serious damages to fishery industries. We recently identified the dinoflagellate Protoceratium reticulatum collected in New Zealand and Japan as the biogenetic origin of YTX. Biosynthetic studies of YTX were carried out by feeding of ^<13>C-labelled compounds. The dinoflagellate P. reticulatum was cultured in the presence of [1-^<13>C], [2-^<13>C] and [1,2-^<13>C_2]AcONa, and [methyl-^<13>C]methionine. The feeding experiments indicated that 15 carbons in YTX were labeled with [1-^<13>C] acetate and 37 carbons were labelled with [2-^<13>C] acetate. However, C1, C2 and C50 were not labelled with acetate. Analogous with brevetoxin B, Me50 was labelled with [methyl-^<13>C]methionine. Elucidation of carbon source of C1 andC2 is now under way.
2000-10-01