69(P-57) 細胞毒ポリエーテル化合物gymnocin-Bの構造決定(ポスター発表の部)

概要

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Worldwide blooms of unicellular microalgae, or red tides, pose serious threats to aquaculture and marine ecosystems. The noxious effects of some species are so devastating that involvement of toxins in the phenomena is easily perceived. However, obstacles laid by the difficulty of culturing the organisms and the small amounts of toxins produced have hampered chemical studies. The dinoflagellate Karenia mikimotoi is one of the representative species that cause devastating damages worldwide and yet remain unknown as to the mechanism of the toxic effect. Using a cytotoxicity assay instead of an elusive fish toxicity assay used in the past and improving extraction and purification conditions, we succeeded to isolate a new toxin designated gymnocin-B (2). Working on 2 and its derivatives by NMR and FAB MS/MS spectrometry, we elucidated its structure consisting of 15 contiguous ether rings and a 2-methyl-2-butenal side-chain.
天然有機化合物討論会の論文
2004-10-01