ニユーカッスル病ワクチン接種による血中抗体の消長と感染防御能に関する研究

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The present report is concerned with some serological investigations on serum samples collected from both field and experimental chickens which had received vaccinations with killed or live Newcastle disease (ND) vaccine. The results are summarized as follows : 1. The herd immunity of ND in chickens was not observed from the result of the hemagglutination-inhibition (HI) test on the sera after a single inoculation of killed vaccine at the age of 1 month. For 2 to 3 month old chickens, the second vaccination produced a positive antibody ratio (1 : 10 or over) in about 70% of the flock, however, the values generally decreased within a few months. By contrast, the ratio of positive antibodies increased from 40 to 70% in the flocks which received vaccinations with live vaccine at 4 days and again at 4 weeks. The same values were also recognized in the flocks which only received a single vaccination at the age of 7 weeks. These positive rates increased from 70 to 90% for the period 3 to 4 months. From the above, it can be seen that the antibody responses to the live ND vaccine in younger chickens were excellent when compared with those of the killed vaccine. 2. Experimental groups of from 30 to 50 chickens of four different ages-1-, 3-, 7- and 10-weeks old-were inoculated intramusculary with 0.5 to 2.0 ml of killed ND vaccine, and were challenged intramusculary with 1.0 ml of virulent ND virus (10^<4.7> EID_<50>) 2 weeks after vaccination. Most of the vaccinated chickens showed titers of 1 : 4 to 1 : 128 in HI and neutralization (NT) tests, and all the positive reactors resisted the challenge of the virulent virus, irregardless of the age of the chickens. Even the negative reactors in the vaccinated group showed resistance to the challenge, whereas all the nonvaccinated chickens of the control group died after challenge with virulent virus. These findings are highly sugge tive of the action of other antibodies or factors on resistance to virulent viral infection. In the present study, neuraminidase-inhibition (NRI) antibody was examined primarily as one of the factors in examined phenomenon, because the NRI antibody has been found to exert an inhibiting effect on virus replication in experimental influenza in mice (SCHULMAN, J. L. : J. Virol., 2 : 778-786, 1968). No relationship was found, however, between the NRI antibodies and the resistance of chickens.
帯広畜産大学の論文
1973-01-18

ニユーカッスル病ワクチン接種による血中抗体の消長と感染防御能に関する研究

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