麻痺性貝毒(パネルディスカッション)(第9回環境汚染物質とそのトキシコロジーシンポジウム)

概要

論文の詳細を見る
Paralytic shellfish poison (PSP), a potent neurotoxin with specific toxicity comparable to that of tetrodotoxin, is mainly produced by toxic species of Protogonyaulax. The PSP produced, is believed to be transferred through the food chain to bivalves which appear not to be affected by the ingestion of plankton. However, man is poisoned when he eats infested bivalves, with typical symptoms such as numbness of limbs, paralysis of lips and death in serious case. The PSP infestation to bivalves followed by outbreaks of human poisoning has long been known in North America and Canada. Similarly, since 1975,frequent PSP infestation to bivalves and sporadic PSP poisoning cases have also been reported in Japan, posing a serious public health problem as well as a great economic loss in fishery industry. PSP has recently been found to be composed of many components, separable from toxic plankton and bivalves ; many of their structures and properties were elucidated. It has thus come to the recognition that PSP might exist in plankton as such low-toxic component (s) as GTX_5,GTX_6,GTX_8 and others.
公益社団法人日本薬学会の論文
1983-02-28