巻貝ハナムシロガイZeuxis siquijorensisからのテトロドトキシン関連物質の分離〔英文〕

概要

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A paralytic toxin was detected in a gastropod, “hanamushirogai” Zeuxis siquijorensis collected from the coast of Shimizu. The toxin was partially purified, essentially by a purification method of tetrodotoxin (TTX), and compared with an authentic specimen of TTX. “Hanamushirogai” toxin clearly differed from TTX in both thin-layer chromatographic and electrophoretic behaviors. Their dose-death time curves in mice did not superimpose on each other. However, it was demonstrated by GC-MS that “hanamushirogai” toxin gives rise to C9-base (2-amino-6-hydroxymethy1-8-hydroxyquinazoline) when hydrolyzed with alkali. It was concluded from these results that the toxin is a TTX-associated substance which contains the quinazoline skeleton (C9-base) as does TTX.
日本水産學會の論文