Presynaptic K^+ Channel Modulation is a Crucial Ionic Basis of Neuronal Damage Induced by Ischemia in Rat Hippocampal CA1 Pyramidal Neurons(Neurobiology)
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概要
- 論文の詳細を見る
The ischemia-induced synaptic potentiation (ISP) during and/or after brain ischemia has been suggested to be one of the crucial factors responsible for irreversible neuronal damage of hippocampal CA1 pyramidal neurons. However, the presynaptic modulation mechanism that leads to neuronal damage during and/or after ischemia was still unknown. By combining electrophysiological methods and infra-red differential interference contrast (IR-DIC) imaging procedures, we showed for the first time that ISP is the result of extraordinary presynaptic depolarization in association with the suppression of 4-aminopyridine (4-AP) sensitive K^+ channels at the presynaptic sites. Furthermore, we also showed that the 4-AP sensitive presynaptic K^+ channels played a crucial role in inducing neuronal damage at a very acute phase of ischemia-induced neuronal damage and would be a therapeutic target against the neuronal damage after brain ischemia.
- 社団法人日本動物学会の論文
- 2003-01-25
著者
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Suzuki Hideo
Department of Information and Network Science, Chiba Institute of Technology
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SAITO Minoru
Department of Internal Medicine, Nagoya Ekisaikai Hospital
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Takagi Hiroshi
Second Department Of Surgery Nagoya University
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Kodama Kunihiko
Department Of Neurosurgery Shinshu University School Of Medicine
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Kodama Kunihiko
Department Of Applied Photonics System Technology Chitose Institute Of Science And Technology
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Suzuki Hideo
Department Of Cardiology Surugadai Nihon University Hospital
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Takagi Hiroshi
Second Department Of Physiology Shinshu University School Of Medicine
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Saito Minoru
Department Of Agricultural Engineering Faculty Of Agriculture Kagawa University
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Saito Minoru
Department Of Applied Physics College Of Humanities And Sciences Nihon University
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Suzuki Hideo
Department of Bioscience Research, Tsukuba Research Laboratory, Toagosei Co., Ltd.
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