CHANGES IN POLYAMINE METABOLISM IN RAT LIVER AFTER ORAL ADMINISTRATION OF ALPHA-NAPHTHYLISOTHIOCYANATE
スポンサーリンク
概要
- 論文の詳細を見る
Changes in the levels of urea cycle enzymes and polyamine metabolism in the liver of rats treated with α-naphthylisothiocyanate (ANIT), an inducer of experimental cholestasis, were studied. Activities of arginase increased approximately two-fold compared to the control values during the period of 24-72 hours after oral administration of ANIT (100 mg/kg), while activities of ornithine carbamyltransferase and ornithine aminotransferase decreased. The activity of ornithine decarboxylase was elevated by approximately 20-and 10-fold at 12 and 60 hours, respectively, after ANIT administration. Putrescine concentration doubled 24-48 hours after the ANIT administration, but spermidine level rose more slowly and reached the level of 1.5-fold of the control level in 36-72 hours. Spermine concentration decreased initially but increased in 96 hours. These results suggest that the increased activity of urea cycle accounts for the increase in the ornithine content and that the putrescine and spermidine acts as the initiator of recovery of the liver damaged by ANIT treatment.
- 日本トキシコロジー学会の論文
- 1986-05-25
著者
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Suzuki Hideo
Department of Information and Network Science, Chiba Institute of Technology
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ITOH Hajime
Department of Chemistry, Faculty of Science, Okayama University
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ITOH Hajime
横須賀共済病院中央検査科
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AOKI YOSHIKAZU
Department of Earth and Planetary Sciences, Faculty of Science, Kyushu University
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Aoki Yoshikazu
Department Of Agricultural Chemistry The University Of Tokyo
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Aoki Y
Department Of Clinical Chemistry Kitasato University School Of Hygienic Sciences
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Itoh Hajime
Department Of Aerospace Engineering National Defense Academy
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Suzuki Hideo
Department Of Cardiology Surugadai Nihon University Hospital
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Suzuki Hideo
Department Of Clinical Chemistry Kitasato University School Of Hygienic Sciences
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Itoh H
横須賀共済病院中央検査科
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Suzuki Hideo
Department of Bioscience Research, Tsukuba Research Laboratory, Toagosei Co., Ltd.
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