麹酸醗酵に関する研究 : (第4報)連続培養による麹酸の生産

概要

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In order to increase the yield of kojic acid, kojic acid production by continuous culture was examined. Nitrogen source (peptone) was used as growth limiting nutrient. There was a linear relation 1/μ and 1/S (eq. (1)). A two-stage continuous culture was carried out. The amount of kojic acid (eg. (8)) theoretically calculated from the holding time distribution of mycelia in the 2nd vessel (eq. (2)) and from the kinetic equations of kojic acid production of batch culture (eq. (4), (6)) was lower than the practical amount obtained by the continuous culture. This suggests that continuous culture differs from batch culture in mycelial growth and kojic acid production. To elucidate the process of the 2nd vessels culture, 48-hour-old mycelia were cultured continuously in the model medium simulative of that in the 2nd vessel in the steady state, and the cultural constants of mycelial growth (α/β) and kojic acid production (αE_0,κ) were obtained. The amount of kojic acid calculated from the above constants and eq. (8) coincided well with the experimental amount.
社団法人日本生物工学会の論文
1970-07-25