腎障害モルモットにおけるアルミニウムの生体内吸収蓄積に及ぼすアスコルビン酸の影響

概要

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Aluminium(Al) accumulates on nervous tissue and bone, and causes unfavorable syndromes on nephropathy patients. It is well known that some organic acids accelerate aluminium absorption. So we, at first, induced nephropathy of guinea pig by giving HgCl_2, and examined the effects of ascorbic acid(AsA) on aluminium absorption and excretion. Guinea pigs were divided into 5 groups. They were low AsA+A1 group, low AsA group, high AsA+Al group, high AsA group, and control group. Except for the control group, kidneys were damaged by intaking of HgC1_2. After 7 weeks, they were sacrificed and Al contents in organs were measured by atomic absorption spectrophotometer. On bone, Al contents were extremely high in AsA administered groups. But in the control group, A1 content showed normal value.
日本ビタミン学会の論文
1999-02-25