〔研究ノート〕ヒト腸管上皮細胞モデル(Caco-2)における鉄とアルミニウムの透過性に関する基礎的研究

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Aluminium is found in large amounts in the Earth's crust, as well as in general food items, food additives and drugs, and is taken into the body orally and via the air on a daily basis. The average daily intake of aluminium in Japan is estimated to be 3 to 4 mg, but it is thought that not all ingested aluminium is absorbed. Akiyama et al.1) have reported that they administered aluminium chloride to transgenic mice for long periods of time and found that the accumulation was low. In this study, in order to investigate the bioavailability of aluminium in humans, we performed cell permeability assays of iron(II)chloride and aluminium chloride using the human intestinal epithelial cell line Caco-2. In the case of iron(II)chloride, 1.3 to 3.2% of iron permeated, and in the case of aluminium chloride, less than 1% of aluminium permeated, thus confirming that the absorption of aluminium is lower than that of iron.
2012-12-01