Antitumor Activity of(10Ε, 12Ζ)-9-Hydroxy-10, 12-Octadecadienoic Acid from Rice Bran
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概要
- 論文の詳細を見る
Two types of hydroxy acids, (10Ε, 12Ζ)-9-hydroxy-10, 12-octadecadienoic acid[1]and(9Ζ, 11Ε)-13-hydroxy-9, 11-octadecadienoic acid[2], were obtained as cytotoxic compounds from a water extract of rice bran. The cytotoxicity of acid 1 was stronger than that of acid 2 in vitro, against P388 mouse leukemia cells. Acid 1 slightly inhibited the growth of a Balb/c mouse 3T3 fibroblast cells(BALB/c 3T3), but strongly inhibited that of simian virus 40-transformed 3T3 cells(SV-T2); 1 was therefore, found to have cytotoxicity against cancer cells. On the other hand, 2 inhibited neither normals cells nor transformed cells. Intraperitoneal injection of acid 1 effectively prolonged the survival time of C3H/HeJ mice after intraperitoneal transplantation of MM46 mammary tumor cells. The difference in antitumor activity between 1 and 2 was also observed in vivo.
- 社団法人日本生物工学会の論文
- 1998-08-25
著者
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TAMURA Hirotoshi
Department of Biochemistry and Food Science, Kagawa Universitry
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Hatada Yuji
Tochigi Research Laboratories Of Kao Corporation
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Mori H
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Mori Hironori
Department Of Biotechnology Faculty Of Agriculture The University Of Tokyo
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Hayashi Y
Research Institute For Food Science Kyoto University
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Matsui Takanao
Faculty Of Engineering Miyazaki University
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HAYASHI Yoshiki
Research Laboratories II, Tamanoi Vinegar Co. Ltd.
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NISHIKAWA YASUSHI
Research laboratories II, Tamanoi Vinegar Co.Ltd.
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MORI HIROTAKA
Research laboratories II, Tamanoi Vinegar Co.Ltd.
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MATSUSHITA YOH-ICHI
Faculty of Engineering, Miyazaki University
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HAKAMADA Yoshihiro
Tochigi Research Laboratories of Kao Corporation
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Matsui T
Faculty Of Engineering Miyazaki University
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Tamura Hirotoshi
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
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Tamura Hirotoshi
Department Of Bioresource Science Faculty Of Agriculture Kagawa University
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Matsushita Yohichi
Faculty Of Engineering Miyazaki University
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Matsushita Yoh-ichi
Faculty Of Engineering Miyazaki University
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Mori Hirotaka
Research Center Tamanoi Vinegar Co. Ltd.
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Hayashi Y
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
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Nishikawa Yasushi
Faculty Of Engineering Miyazaki University
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Hayashi Yoshiki
Research Laboratories Ii Tamanoi Vinegar Co. Ltd.
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