Evaluation of the Cytotoxic Activity of Chiral (E)-13-Hydroxy-10-oxo-11-octadecenoic Acid and Its Lactone
スポンサーリンク
概要
- 論文の詳細を見る
Both the S and R enantiomers of (E)-13-hydroxy-10-oxo-11-octadecenoic acid (1) and (E)-10-oxo-11-octadecen-13-olide (2) had similar IC_<50> values against P388 mouse leukemia cells ; i.e. the stereochemistry of the asymmetric center of 1 and 2 had no influence on the cytotoxic activity. Bioassay results of various compounds related to 1 and 2 suggests that the 10-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity.
- 社団法人日本農芸化学会の論文
- 1998-09-23
著者
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Hatada Yuji
Tochigi Research Laboratories Of Kao Corporation
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Mori H
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Sugamoto Kazuhiro
Faculty Of Engineering University Of Miyazaki
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Mori Hironori
Department Of Biotechnology Faculty Of Agriculture The University Of Tokyo
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Hayashi Y
Research Institute For Food Science Kyoto University
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Matsui Takanao
Faculty Of Engineering Miyazaki University
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HAYASHI Yoshiki
Research Laboratories II, Tamanoi Vinegar Co. Ltd.
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NISHIKAWA Yasushi
Faculty of Engineering, Miyazaki University
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MORI Hirotaka
Faculty of Engineering, Miyazaki University
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MATSUSHITA Yohichi
Faculty of Engineering, Miyazaki University
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MATSUSHITA YOH-ICHI
Faculty of Engineering, Miyazaki University
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HAKAMADA Yoshihiro
Tochigi Research Laboratories of Kao Corporation
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Matsui T
Faculty Of Engineering Miyazaki University
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Sugamoto Kazuhiro
Faculty Of Engineering Miyazaki University
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Matsushita Yohichi
Faculty Of Engineering Miyazaki University
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Hayashi Y
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
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Nishikawa Yasushi
Faculty Of Engineering Miyazaki University
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Hayashi Yoshiki
Research Laboratories Ii Tamanoi Vinegar Co. Ltd.
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