Studies of differentiation between rats and guinea pigs on immunoglobulin-A excretion into bile.

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125I-labeled dimeric immunoglobulin A (IgA) was injected into the mesenteric vein of rats or guinea pigs and excretion of its radioactivity into bile was estimated. While 125I-IgA was excreted into bile at a considerably higher speed in the case of rats, its excretion in guinea pigs was extremely low. But radioactivity detectable in liver tissue 2 hours after intravenous injection of 125I-dimeric IgA was not so different between rats and guinea pigs (rats 21.6% and guinea pigs 17.6% for the amount of injected 125I-radioactivity). Furthermore 125I-dimeric IgA was significantly incorporated into the isolated hepatocytes prepared from both rats and guinea pigs, but the release of radioactivity incorporated from hepatocytes were remarkably lower in guinea pigs compared with rats.These results suggested that IgA transport in liver was different markedly between rats and guinea pigs.
財団法人日本消化器病学会の論文