四塩化炭素肝障害における肝類洞内皮細胞の血小板活性化因子およびインターロイキン1の産生能

概要

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The changes in the levels of platelet activating factor (PAF) and interleukin-1 (IL-1) produced by hepatic sinusoidal endothelial cells from mice with carbon tetrachloride-induced liver cell injury were studied. As a result, the levels of serum transaminase significantly increased and liver cell injury was induced 24 hours after the administration of carbon tetrachloride, while the levels of PAF and IL-1 remarkably decreased 48 hours after the administration of carbon tetrachloride. At 72 hours after the administration of carbon tetrachloride, the infiltration of mononuclear cells was found in liver cell necrosis when the levels of PAF and IL-1 recovered, while extensive hepatic cell necrosis with hemorrhage was observed when the levels of PAF and IL-1 decreased. These results suggested that morphological changes of liver cell injury were connected with the function of hepatic sinusoidal endothelial cells.