Interferon receptors during treatment of chronic hepatitis B with interferon.

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We analyzed the binding of 125I-labeled IFN to peripheral blood mononuclear cells (PBMC) before, during, and after IFN therapy in 10 patients with chronic type B hepatitis. Six of the patients were given daily injections of IFN for 4 weeks. The binding of 125I-labeled IFN to PBMC decreased to 50% during therapy, and retured to the base-line level by 2 week after the end of therapy. The other 4 patients were treated with IFN for 2 weeks, not treated for the next 2 weeks, and treated again for 2 more weeks. Binding decreased to 45% during therapy. It had retured to 92% of the base-line level 1 week after the first round of therapy and to 101% 1 week later. Binding was 85% 1 week after the second round of therapy and 92% 1 week later. Assays of serum DNA-P showed that viral replication did not increase greatly during the 2 weeks without IFN. The study of IFN receptors may help to make IFN treatment more effective.
財団法人日本消化器病学会の論文