Morphological polymorphysm of hepatocytes and regeneration in survivors from fulminant hepatitis and acute hepatitis with bridging hepatic necrosis.

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The residual hepatocytes in early disease stages of 14 surviving patients with fulminant hepatitis or severe acute hepatitis in whom the initial liver biopsy disclosed bridging hepatic necrosis were morphologically investigated by light and electron microscopy. The following conclusions are obtained.<BR>The residual hepatocytes were not so markedly damaged as have been conventinally considered. Especially, it is eatimated that cytokinesis due to mitosis would occur in the following cells: large hepatocytes having large-sized nuclei and clear nucleoli, possessing well-developed rER, a lot of free ribosome and mitochondria of which matrix's electron density is low, in the cytoplasm around the nuclei, and in addition, showing abundant glycogen granules and fat droplets in the cytoplasm around the cell membrane. Binuclear cells which present the same ultrastructural features including those of organelle, etc. Would be divided into mono-nuclear daughter cells. On the other hand, small hepatocytes having basophilic cytoplasm and forming a thickened, restiform arrangement were regarded as newly generated cells by mitosis. These cells can be divided into three groups as stated in "RESULTS" in terms of ultrastructure. These small hepatocytes would gradually mature and repeat mitosis as large hepatocytes would. Thus, extensive necrotized areas would be gradually repaired and finally, cobble stone appearance, etc. would be formed, in which compensation has completed.
社団法人日本肝臓学会の論文

Morphological polymorphysm of hepatocytes and regeneration in survivors from fulminant hepatitis and acute hepatitis with bridging hepatic necrosis.

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