Evaluation of portal circulation by oral administration of capsule enclosing Tc-99m pertechnetate.

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Capsules of Tc-99m pertechnetate that contained a releasing mechanism were prepared and given orally to volunteers to evaluate the portal circulation.A preliminary study of Macaca fascicularis showed that Tc-99m pertechnetate injected in the rectum circulated through the inferior mesenteric vein to the portal vein and liver, whereas the compound injected into the small intestine circulated through the superior mesenteric vein to the portal vein and liver. The results suggested that portal scintigraphy through the small intestine could be analyzed in the same way as per-rectal portal scintigraphy.The study of the volunteers was successfully completed in 3 of the 4 subjects. The Tc-99m pertechnetate was released when the capsule reached the small intestine. From there, the compound circulated through the superior mesenteric vein to the portal vein and liver. The results showed that this use of a capsule enclosing a radioisotope is possible and probably safe.
財団法人日本消化器病学会の論文