The protective effects of Sho-saiko-to in an experimental, immunologically-induced allergic hepatic cell injury.

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When trinitrophenylated hepatocytes were intravenously injected into trinitrophenylated liver protein-sensitized guinea pigs through mesenteric vein, hepatic cell necrosis was seen to a large extent in all of the guinea pigs and the values of serum GOT and GPT increased to 1, 067±265 and 101±24U/l 24 hours later. However, when trinitrophenylated hepatocytes were injected into trinitrophenylated liver protein-sensitized guinea pigs which had been administered with Sho-saiko-to 30, 24 and 6 hours before, only spotty necrosis could be seen and massive hepatic cell necrosis was not seen in any of the guinea pig. In addition, the values of GOT and GPT remarkably improved.These results suggested that Sho-saiko-to is effective for the immunologically-induced allergic hepatic cell injury model.