Immunohistochemical study of cholestatic factor in the liver of patients with various liver diseases by monoclonal antibody.

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The cholestatic factor (CF) in liver biopsy specimens from patients with variolLs liver diseases was investigated immunohistochemically. Monoclonal antibody to CF from lymphonode cells of the tuberculin-sensitized guinea pigS was used in this immunohistochemical study.<BR>Intrahepatic CF was detected in 11 of 31 patients who were 5 of drug induced liver inj ury, 2 of acute viral hepatitis, 3 of alcoholic liver injury and 1 of autoimmune hepatitis. In all these diseases CF was diffusely and granularly localized in the cytoplasm of many hepatocytes. All CF-positive patients had jaundice in their courses. But, CF was neither present in the liver specimens of patients with symptomatic primary biliary cirrhosis nor extrahepatic obstruction.<BR>These findings strongly suggest that CF correlates with intrahepatic cholestasis in drug induced liver injury, acute viral hepatitis, alcoholic liver injury and autoimmune hepatitis.
社団法人日本肝臓学会の論文