Histopathological studies on bile duct lesions in primary biliary cirrhosis. Electron microscopic studies on the disintegration of the bile ducts.:Electron Microscopic Studies on the Disintegration of the Bile Ducts

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Ultrastructural changes of intrahepatic bile ducts in primary biliary cirrhosis (11 cases) and chronic hepatitis (7 cases) were investigated.Results were as follows:1) Disruption of basement membrane and falling of epithelial cells into periductal space were revealed in a large bile duct which showed chronic non-suppurative destructive cholangitis (CNSDC) and a large bile duct without CNSDC in PBC.2) Infiltration of lymphocytes into bile duct epithelium was more prominent in PBC than in chronic hepatitis.3) In PBC, "dark cell"metamorphosis was often observed in the epithelial cells in contact with the lymphocytes infiltrating into bile duct epithelium.Form these results, in PBC, disruption of basement membrane and falling of epithelial cells into periductal space may be specific changes in process of disintegration of bile ducts and sensitized T lymphocytes seem to be responsible for the bile duct damage.
財団法人日本消化器病学会の論文