A basic study for cytotoxic effect of tumor necrosis factor-.ALPHA. on the hepatoma cell line, PLC/PRF/5.

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In order to investigate the effect of tumor necrosis factor (recombinant TNF-α) on hepatoma, we assessed the antitumor activity of TNF-α on hepatoma cell line, PLC/PRF/5 in vitro, and combined effects of interferon-γ (IFN-γ), that is thought to increase TNF-receptors. TNF-receptors. TNF-α for itself, had no significant effect on DNA synthesis and viability, and Lipopolysaccharidethe production of HBsAg from PLC/PRF/5.On the other hand, treatment of IFN-γ- combined with TNF-α inhibited DNA synthesis and production of HBsAg. The decrease of viability of PLC/PRF/5 was also found in this combination treatment.According to these findings, antitumor activity of TNF-α had no effect on PLC/PRF/5 in itself, but was significantly enhanced when treated with IFN-γ at the same time.
財団法人日本消化器病学会の論文