Effect of anticholinergic drugs on striatal acetylcholine release and motor activity in freely moving rats studied by brain microdialysis.
スポンサーリンク
概要
- 論文の詳細を見る
We have studied effects of intraperitoneal administration of anticholinergic drugs on striatal acetylcholine release in association with motor activity in freely moving rats using brain microdialysis. A low dose of atropine (2.5 mg/kg) increased striatal acetylcholine release. A high dose of atropine (5 mg/kg) or scopolamine (2.5, 5 and 10 mg/kg) increased both striatal acetylcholine release and motor activity, while its quaternary ammonium compounds, atropine methylbromide (5 and 10 mg/kg) and methscopolamine bromide (5 and 10 mg/kg), increased striatal acetylcholine release without motor excitation. Scopolamine (2.5 mg/kg) produced no significant change in striatal acetylcholine content 4 hr after the injection followed by perfusion. These results suggest that anticholinergic drugs cause an increase in striatal acetylcholine release which does not always result in the increase of motor activity.
- 公益社団法人 日本薬理学会の論文
著者
-
Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
-
SHIMIZU Hiroko
Department of Pharmacology, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
-
SHIMIZU Hiroko
Department of Chemistry, University of Hawaii at Manoa
関連論文
- Novel Preparation of Intercellular Lipid Models of the Stratum Corneum Containing Stereoactive Ceramide
- Endovascular Stent-Grafting for Recurrent Aneurysm in Behcets Disease
- Heterotopic sebaceous glands in the esophagus : Histopathological and immunohistochemical study of a resected esophagus
- Solitary esophageal metastasis of breast cancer with 15 years' latency : A case report and review of the literature
- PE-150 Comparison of Dilated Cardiomyopathy and Coronary Artery Disease in Effectiveness of Dl-sotalol on the Recurrence of Ventricular Tachyarrhythmia(Arrhythmia, therapy-10 (A) PE25,Poster Session (English),The 70th Anniversary Annual Scientific Meeting
- Efficacy of Bepridil for Antiarrhythmic Drug Refractory Ventricular Tachyarrhythmias in ICD Patients with Structural Heart Disease(Arrhythmia, Pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Possible Prevalence and Transmission of Acute Respiratory Tract Infections Caused by Streptococcus pneumoniae and Haemophilus influenzae among the Internally Displaced Persons in Tsunami Disaster Evacuation Camps of Sri Lanka
- RNA Editing and Short Variant of Serotonin 2C Receptor mRNA in Neuronally Differentiated NG108-15 Cells
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
- PJ-093 Extracellular but not Intracellular Acidosis Suppresses Endothelial Function by Inhibiting Intracellular Calcium Responses(Endothelium(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- IS121 Regulation of capacitative Ca^2+ influx in human monocytes/macrophages by myosin light-chain kinase
- Regulation of Bradykinin-Stimulated Cation Entry Into Endothelial Cells by tyrosine Kinase
- Excessive nitric oxide production and cardiac dysfunction in patients with chronic renal failure
- P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caco-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines
- PJ-566 Influence of CYP2C9 Genotype on Pharmacokinetics and Pharmacodynamics of Benzbromarone(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-561 Antiproliferative Effect of Cyclic AMP on Human Umbilical Vein Endothelial Cells through TGF-beta Inducing p21(Cip1/Waf1) Expression(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
- OJ-002 Influence of Genetic Polymorphisms of OATP-C on Cholesterol Lowering Effect of Pravastatin(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- 4 Inhibition of Type-5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension(Which drug is useful for the treatment of pulmonary hypertension?,Topic 4 (TP4) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Survival in Patients with Pulmonary Hypertension Treated with a Type 5 Phosphodiesterase Inhibitor Sildenafil(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-271 Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolaemia and hypertension(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- Assessment of Forearm Reactive Hyperemia Using Near-Infrared Time-Resolved Spectroscopy : A New Tool to Evaluate Endothelial Function
- A Case of Addison's Disease Confirmed with Low Dose Cosyntropin Stimulation Test
- Association of Chlamydia Pneumoniae Infection and Carotid Intima-Media Wall Thickness in Japanese Americans
- PE-386 Clinical Impact after Cessation of Antiplatelet Therapy in Patients with Drug-eluting Stent Implantation(Cardiovascular pharmacology, basic/clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- PE-085 Free Fatty Acids (FFAs), Arachidonic and Linoleic Acids but not other FFAs, Suppress Endothelial Function by Inhibiting Endothelial Ca^ Responses(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Ci
- OE-243 Regenerated Endothelium Produces not Vasodilative but Vasoconstrictive Prostanoid(s) via Cyclooxygenase-dependent Pathway(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japane
- PE-384 Direct Effect of ACE Inhibitors on Endothelium : ACE Inhibitors Enhance Kallikrein-induced Ca2+ Responses via Endogenous Bradykinin in Engothelial Cells(Cardiovascular pharmacology, basic/clinical-3, The 71st Annual Scientific Meeting of the Japane
- Large Quantities of NO Inhibit Agonist-Induced Endothelial Cell Ca^ Responses via a Peroxynitrite Pathway
- Inhibition of Type 5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension
- A potential role of sildenafil in the management of pulmonary hypertension
- A novel nonpeptide bradykinin receptor agonist in the regulation of endothelial calcium signaling and coronary artery tone
- Nitric oxide : a negative feedback on endothelium-derived vascular relaxing factors
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- Fermi-Surface Reconstruction in the Periodic Anderson Model(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Effect of the Insulin-like growth factor I receptor (IGF-IR) on radiosensitivity of human glioblastoma cells grown in multicellular spheroids.
- Interaction between Amlodipine and Simvastatin in Patients with Hypercholesterolemia and Hypertension
- Why Does Hemocyte Density Rise during the Wandering Stage of the Silkworm, Bombyx mori?
- Regeneration of Hemopoietic Organs in the Silkworm, Bombyx mori, After Locally Targeted Irradiation with Heavy Ion Beams
- Clinical Evaluation of Breech Deliveries Over a Fifteen-Year Period at a Hospital in Ota, Japan
- Autoimmune Hepatitis Overlapping with Primary Sclerosing Cholangitis
- Practical Assay Method of Cytosolic Acetoacetyl-CoA Thiolase by Rapid Release of Cytosolic Enzymes from Cultured Lymphocytes Using Digitonin
- An α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Antagonist and an N-Methyl-D-aspartate (NMDA) Channel Blocker Synergistically Impair Spatial Memory in Rats
- Magnetic Resonance Imaging Findings in Primary Amyloidosis-associated Arthropathy
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice
- Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice
- GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Chronic Cerebral Hypoperfusion-Induced Neuropathological Changes in Rats
- Tacrine Improves Working Memory Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
- Uptake of Liposomally Entrapped Fluorescent Antisense Oligonucleotides in NG108-15 Cells : Conventional versus pH-Sensitive
- Effect of Japanese Angelica Root Extract on Pentobarbital-Induced Sleep in Group-Housed and Socially Isolated Mice:Evidence for the Central Action
- Influence of Chronic Treatment With Imipramine on mRNA Levels in Rat Brain : Elevation of Glyceraldehyde-3-phosphate Dehydrogenase Levels
- Enhancement of Serotonin 2C Receptor mRNA Expression by Antidepressants Possessing the Receptor-Blocking Activity in the Rat Brain
- Molecular Cloning and Characterization of a Novel Sequence, vof-16, with Enhanced Expression in Permanent Ischemic Rat Brain(Pharmacology)
- In Vitro Antioxidant Activity of Vietnamese Ginseng Saponin and Its Components
- Inhibition by Bacterial Lipopolysaccharide of Spontaneous and TNF-α-Induced Human Neutrophil Apoptosis In Vitro
- Auxiliary Heterotopic Partial Liver Transplantation in Pigs with Acute Liver Failure
- Peak Systolic Blood Pressure in Exercise Testing is Associated With Scintigraphic Severity of Myocardial Ischemia in Patients With Exercise-Induced ST-Segment Depression
- ベトナムの小児急性下気道感染症における薬剤耐性肺炎球菌
- Non-Equilibrium Relaxation Analysis on Two-Dimensional Melting(The 50th Anniversary of the Alder Transition -Recent Progress on Computational Statistical Physics-)
- Prevalence of Haemophilus influenzae with resistant genes isolated from young children with acute lower respiratory tract infections in Nha Trang, Vietnam
- Clinical and microbiological characteristics of community-acquired pneumonia among human immunodeficiency virus-infected patients in northern Thailand.
- Increased Rates of Intense Nasopharyngeal Bacterial Colonization of Vietnamese Children with Radiological Pneumonia
- Strain-Specific Pulmonary Defense Achieved after Repeated Airway Immunizations with Non-Typeable Haemophilus Influenzae in a Mouse Model
- Molecular Characterization of the Transmission between the Colonization of Methicillin-resistant Staphylococcus aureus to Human and Environmental Contamination in Geriatric Long-term Care Wards
- Enterocolitis Caused by Methicillin-Resistant Staphylococcus aureus: Molecular Characterization of Respiratory and Digestive Tract Isolates
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- Induction of Right Ventricular Hypertrophy in Neonatal Guinea Pigs by Monocrotaline
- Spontaneous Regression of Peripheral Pulmonary Artery Stenosis in Williams Syndrome
- Congenital Coronary Artery Fistula : Surgical Results and Late Changes in Coronary Artery Aneurysm
- OJ-225 Clinical Analysis of Tako-tsubo Cardiomyopathy Cases after the Niigata-Chuetsu Earthquake(Cardiomyopathy, basic/clinical-2 (M) OJ38,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Intermission in Layer-by-Layer Growth of Bi_2Sr_2Ca_2Cu_3O_ Thin Films on Nd:YAlO_3(001)
- Relationship between Cell Morphology and Intracellular Potassium Concentration in Candida albicans
- Valinomycin Affects the Morphology of Candida albicans
- Analysis of Chitin at the Hyphal Tip of Candida albicans Using Calcofluor White
- A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy
- A case of idiopathic portal hypertension associated with rheumatoid arthritis
- 4 Clinical Impact after Cessation of Antiplatelet Therapy in Patients with Drug-eluting Stent Implantation(Current Status and Future Perspective of Drug-Eluting Stents,Plenary Session 1 (PL-1) (A),The 73rd Annual Scientific Meeting of The Japanese Circula
- Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
- Improvement in the Histopathology of Hearts from Cardiomyopathic BIO TO-2 Hamsters Following Long-Term Administration of Amlodipine and Cilnidipine
- Importance of Lipid Levels in Elderly Diabetic Individuals : Baseline Characteristics and 1-Year Survey of Cardiovascular Events
- Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature
- Cold Exposure Enhances Nitroxidergic Nerve-Mediated Vasodilatation in Canine Nasal Mucosa
- Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
- Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia
- Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Improves Vascular Response to Reactive Hyperemia in Patients with Raynaud's Phenomenon
- PE-187 The Interaction of NO and 20-HETE in the Reduction of Cerebral Blood Flow Following Subarachnoid Hemorrhage in Rats(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japan
- PE-073 Novel Property of Amlodipine to Improve Disturbed Endothelial Barrier Function by Mechanisms Other than the Effect on Voltage-dependent Calcium Channel(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),The 70th Anniver
- Is SPECT Cost-Effective in Managing Ischemic Heart Disease (IHD) in Japan? Comparison with Exercise ECG-Testing (EET) and Coronary Angiography (CAG)
- 3 Stress Myocardial SPECT Is Cost-effective in Diagnosis And Management of Ischemic Heart Disease (IHD) in Diagnosis Procedure Combination (DPC) Era(Plenary Session 6 (PL6) (I) : Role of Diagnostic Imaging in the Management of Coronary Artery Disease and
- Ultrastructural and cytochemical characterization of human cord blood cells
- Novel Charge Order and Superconductivity in Two-Dimensional Frustrated Lattice at Quarter Filling(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Coexistence of the Upper Charge-Density-Wave and the Superconductivity in NbSe_3(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- A Comparative Study on the Effects of Nicotine and GTS : 21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level