ラットを用いる定量的肝傷害作製と,血清アミノトランスフェラーゼ値との関係

概要

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The rate and degree of increase in serum alanine aminotransferase and aspartate aminotransferase levels following controlled mechanical damage to the liver were studies in rats. To induce injury to the liver, 30% and 70% partial hepatectomy, and acupuncture using staples of varying number were used. It was found that these enzymes increased in serum immediately following damage, reaching a maximum at about 4 and 24 hours depending upon the damaging method. Whereas the increases were closely correlated with the degree of damage caused by acupuncture, the enzyme increases were greater with 30% resection than with 70% resection. Acupuncture is a useful technique to induce controlled amounts of mechanical damage to the liver. It will have applications in basic research and various clinical implications.
千葉大学の論文