Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species(Organic Chemistry)

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概要

• 論文の詳細を見る

• Curvularin, 8-dehydrocurvularin, and 8-hydroxycurvularin as well as a minor new metabolite, 8-methoxycurvularin, were isolated as fungal metabolites having cytotoxic activity toward sea urchin embryogenesis. Curvularin induced barrel-shaped mitotic spindles and 8-dehydrocurvularin caused miniature spindles. They were shown to act on components of the mitotic apparatus and to effectively inhibit cell division.

• 社団法人日本農芸化学会の論文
• 1988-12-23

著者

• KOBAYASHI AKIO

  Department of Biotechnology, Graduate School of Engineering, Osaka University

• KAWAZU Kazuyoshi

  Department of Bioresources, Okayama University

• ITOH Tomohiko

  Graduate School of Life Science, Nagoya University

• Kawazu Kazuyoshi

  The Graduate School Of Natural Sci. And Technol. Dep. Of Biofunctional Chemistry Lab. Of Applied Nat

• Kawazu Kazuyoshi

  Laboratory Of Bioresources Chemistry Department Of Agricutlural Science Okayama University

• Kawazu Kazuyoshi

  Department Of Agricultural Chemistry Okayama University

• Kawazu Kazuyoshi

  Department Of Bioresources Chemistry Okayama University

• Itoh T

  Graduate School Of Life Science Nagoya University

• Kobayashi A

  Laboratory Of Food Chemistry Ochanomizu University

• YATA Shinji

  Department of Agricultural Science, Okayama University

• HINO Tomokazu

  Department of Agricultural Chemistry, Okayama University

• ITOH Tomohiko

  Sugashima Marine Biological Laboratory, School of Science, Nagoya University

• SATO Hidemi

  Sugashima Marine Biological Laboratory, School of Science, Nagoya University

• Hino Tomokazu

  Department Of Agricultural Chemistry Okayama University

• 佐藤 英美

  Hokkaido Univ. Sapporo

• Sato Hidemi

  Sugashima Marine Biological Laboratory Nagoya University

• Yata Shinji

  Department Of Agricultural Chemistry Okayama University

• Kobayashi Akio

  Department Of Biotechnology Graduate School Of Engineering Osaka University

• KOBAYASHI Akio

  Department of Biochemistry, Shinshu University School of Medicine

• KOBAYASHI Akio

  Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University

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