Asymmetric Production of _L-Carnitine from trans-Crotonbetaine by Proteus mirabilis(Microbiology & Fermentation Industry)

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概要

• 論文の詳細を見る

• A novel enzymatic method for the production of L-carnitine (L-4-trimethylamino-3-hydroxybutyric acid) has been developed. Microorganisms that asymmetrically produce L-carnitine from trans-crotonbetaine(trans-4-trimethylamino-2-butenoic acid), which was easily supplied through the chemical dehydration of DL-carnitine with an acid, were screened from stock cultures in our laboratory. Of the 686 strains of microorganisms examined, i.e., 416 bacteria, 37 actinomycetes and 233 yeasts, strains belonging to the genera, proteus and Escherichia, were found to be efficient producers of L-carnitine from trans-crotonbetaine. Through the screening, Proteus mirabilis AJ-2772 and AJ-12137, with potent abilities, were selected as representative strains. The trans-crotonbetaine-hydrating enzyme was inducibly and intracellularly produced on either the addition of trans-crotonbetaine or L-carnitine to tne medium under partially anaerobic conditions. With intact cells of P. mirabilis AJ-2772, 40 g/l of L-carnitine chloride was produced from 62.5 g/l of trans-crotonbetaine.

• 社団法人日本農芸化学会の論文
• 1988-10-23

著者

• YOKOZEKI Kenzo

  Central Research Laboratories, Ajinomoto Co., Inc.,

• Hirose Y

  Faculty Of Education And Human Sciences Yamanashi University

• Yokozeki K

  Ajinomoto. Co. Inc. Kawasaki Jpn

• Yokozeki Kenzo

  Aminoscience Laboratories Ajinomoto. Co. Inc.

• Hirose Yuko

  Department Of Chemistry Faculty Of Education Yamanashi University

• Takahashi Shinichiro

  Central Research Laboratories Of Ajinomoto Co. Inc.

• HIROSE Yoshiteru

  Central Research Laboratories of Ajinomoto Co., Inc.

• KUBOTA Koji

  Central Research Laboratories of Ajinomoto Co., Inc.

• Kubota K

  Central Research Laboratories Of Ajinomoto Co. Inc.

• Yokozeki Kenzo

  Central Research Laboratories Of Ajinomoto Co.

• Kubota Koji

  Central Research Laboratories Ajinomoto Co. Inc.

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