Enzymatic Production of Ribavirin from Pyrimidine Nucleosides by Enterobacter aerogenes AJ 11125(Microbiology & Fermentation Industry)
スポンサーリンク
概要
- 論文の詳細を見る
Microorganisms that produce ribavirin(1-β-D-ribofuranosyl-1, 2, 4-triazole-3-carboxamide; virazole[○!R]) directly from pyrimidine nucleosides and TCA (1, 2, 4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mM and 67.6mM ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60℃. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside.
- 社団法人日本農芸化学会の論文
- 1988-05-23
著者
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YOKOZEKI Kenzo
Central Research Laboratories, Ajinomoto Co., Inc.,
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Yokozeki K
Ajinomoto. Co. Inc. Kawasaki Jpn
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Yokozeki Kenzo
Aminoscience Laboratories Ajinomoto. Co. Inc.
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KUBOTA Koji
Central Research Laboratories of Ajinomoto Co., Inc.
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Kubota K
Central Research Laboratories Of Ajinomoto Co. Inc.
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Yokozeki Kenzo
Central Research Laboratories Of Ajinomoto Co.
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SHIRAE Hideyuki
Central Research Laboratories of Ajinomoto Co., Inc.
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Shirae H
Central Research Lab. Ajinomoto Co. Ltd. Kawasaki Jpn
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Shirae Hideyuki
Central Research Laboratories Of Ajinomoto Co. Inc.
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Kubota Koji
Central Research Laboratories Ajinomoto Co. Inc.
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