The Incidence of Hyperuricemia and Correlated Factors in Middle-Ages Japanese Men
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概要
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To identify the factors responsible for increases in serum uric acid(SUA), 1,346 hyperuricemia-free(less than 7.5 mg/d/of SUA and no medication for hyperuricemia or hypertension)Japanese male office workers aged 30 to 53 yr were followed up for seven successive years with annual examinations, with an average period of observation of 6.4 yr with a standard deviation of 1.6 yr. Subjects who were found to have become hyperuricemic(SUA levels of 7.5 mg/d/or more)or who started medication for hyperuricemia during repeat survey were defined as incidence cases. An analysis by means of the Kaplan-Meier method showed that the incidence of hyperuricemia increased significantly with increases in the body mass index(BMI), systolic blood pressure, diastolic blood pressure, triglyceride level, SUA level, total protein level, white blood cell level, and alcohol intake. From the age-adjusted analysis with the Cox proportional hazards model, the total cholesterol level and hemoglobin A_<1c>(HbA_<1c>)level emerged as significant positive and negative factors for the incidence of hyperuricemia, respectively. Multivariate analysis, excluding the SUA level as a factor in the Cox proportional hazards model, indicated that the BMI, Log triglyceride level, white blood cell level, and alcohol intake were significantly positively associated with the incidence of hyperuricemia. On the other hand, age and the HbA_<1c> level were significantly inversely associated with the incidence of hyperuricemia. When the SUA level was included as a factor in the model, BMI and alcohol intake remained as independent factors. Furthermore, the white blood cell level was identified as marginally significant for the incidence of hyperuricemia(p=0.064). In conclusion, obesity and alcohol intake were determined to be independent predictors for the development of hyperuricemia. In addition, the white blood cell level may be a contributory factor.
- 社団法人日本産業衛生学会の論文
著者
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Suzuki K
School Of Science And Engineering Waseda University:kagami Memorial Laboratory For Materials Science
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Suzuki Kenji
Kdd R & D Laboratories
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Suzuki Kenji
Japan Labor And Welfare Association
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Suzuki Kenji
Institute For Materials Research Laboratory Tohoku University
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TATARA Kozo
Department of Public Health, Osaka University Medical School
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Suzuki K
Ntt Transmission Systems Laboratories Lightwave Communications Laboratory
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Suzuki K
Assoc. Super‐advanced Electronics Technol. Kanagawa Jpn
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NAKANISHI Noriyuki
Department of Public Health Osaka University Medical School
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Nakamura K
Center For Experimental Medicine Institute Of Medical Science University Of Tokyo
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Suzuki K
Department Of Information And Communication Technology Tokai University
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Nakamura Koji
Division Of Social And Environmental Medicine Department Of Community Preventive Medicine Niigata Un
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Tatara Kozo
Department Of Public Health And Neurosurgery Osaka University Medical School
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Suzuki K
東京大学大学院農学生命科学研究科獣医病理学研究室
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Nakajima Kazue
Department Of Public Health Osaka University Medical School
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Nakanishi Noriyuki
大阪大学 医学系研究科社会環境医学
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Nishi Nobuo
Department Of Social And Environmental Medicine Course Of Social Medicine Osaka University Graduate
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NAKAMURA Koji
Medical Office, Osaka Main Office, Takenaka Corporation
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Suzuki Kenji
Japan International Research Center For Agricultural Sciences
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Nakamura Kouji
Medical Office, Osaka Main Office, Takenaka Corporation
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