海洋生物由来の抗癌剤の探索
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概要
- 論文の詳細を見る
- 公益社団法人日本薬学会の論文
- 1989-06-01
著者
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小林 資正
大阪大学薬学部
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Kobayashi M
Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North
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Kobayashi M
Faculty Of Pharmaceutical Sciences Osaka University
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小林 資正
大阪大学薬学研究科
関連論文
- Structures of Echinoside A and B, Two Antifungal Oligoglycosides from the Sea Cucumber Actinopyga echinites (JAEGER)
- 海綿由来のトリデカペプチドラクトンであるテオネラペプトライドIeが誘発する表層アクチンの撹乱によって引き起こされるヒトデ未成熟卵の形態異常
- Marine Natural Products. XXIV. : The Absolute Stereostructure of Misakinolide A, a Potent Cytotoxic Dimeric Macrolide from an Okinawan Marine Sponge Theonella sp.
- Marine Natural Products. XXIII. : Three New Cytotoxic Dimeric Macrolides, Swinholides B and C and Isoswinholide A, Congeners of Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei
- 17 Theonella属海綿の産生する二量体マクロリド類の化学構造と抗腫瘍活性(口頭発表の部)
- Marine Natural Products. XXII. : The Absolute Stereostructure of Swinholide A, a Potent Cytotoxic Dimeric Macrolide from the Okinawan Marine Sponge Theonella swinhoei
- 19 沖縄産Theonella属 海綿2種の産生するアミノセスキテルペン類および生物活性ペプチドラクトン類の化学構造
- STRUCTURE OF THEONELLAPEPTOLIDE ID, A NEW BIOACTIVE PEPTOLIDE FROM AN OKIKAWAN MARINE SPONGE, THEONELLA SP. (THEONELLIAE)
- Marine Natural Products. XXXII. Absolute Configurations of C-4 of the Manoalide Family, Biologically Active Sesterterpenes from the Marine Sponge Hyrtions erecta
- Marine Natural Products. XXXI. Structure-Activity Correlation of a Potent Cytotoxic Dimeric Macrolide Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei, and Its Isomers
- 沖縄産海綿Hyrtios altumより得られた抗腫瘍活性を有するマクロリド、アルトヒルチンA(発表論文抄録(1993))
- インドネシア薬用植物 第XI報 : Caesalpinia major(マメ科)根から単離した2種の新規カッサン型フラノジテルペンcaesaldekarin a及びbの化学構造(発表論文抄録(1994))
- Indonesian Medicinal Plants. XI. Chemical Structures of Caesaldekarins a and b, Two New Cassane-Type Furanoditerpenes from the Roots of Caesalpinia major (Fabaceae)
- A Functional Role of Intracellular Loops of Human Multidrug Resistance Protein 1
- P-54 ANALYSIS OF MOLECULAR MECHANISM OF MRP1 BY AGOSTEROL A, A MDR REVERSING SPONGEAN STEROL
- Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells
- Lembehsterols A and B, Novel Sulfated Sterols Inhibiting Thymidine Phosphorylase, from the Marine Sponge Petrosia strongylata
- 海洋天然物研究(30) : 沖縄産海綿Theonella swinhoeiより得られた2種の新規3-ケト-4-メチレンステロイド,テオネラステロンおよびコニカステロンと,ディールス-アルダー型の二量体ステロイド,ビステオネラステロン(発表論文抄録(1991年))
- 海洋天然物研究(29) : 渦鞭毛藻Heterosigma akashiwoより得られたω3型不飽和脂肪酸を構成脂肪酸とする4種の糖脂質,ヘテロシグマグリコリピド I, II, IIIおよびIV(発表論文抄録(1991年))
- Marine Natural Products. XXX. Two New 3-Keto-4-methylene Steroids, Theonellasterone and Conicasterone, and a Diels-Alder Type Dimeric Steroid Bistheonellasterone, from the Okinawan Marine Sponge Theonella swinhoei
- Marine Natural Products. XXIX. Heterosigma-glycolipids I, II, III, and IV, Four Diacylglyceroglycolipids Possessing ω3-Polyunsaturated Fatty Acid Residues, from the Raphidopycean Dinoflagellate Heterosigma akashiwo
- 44 海綿由来のキノリチジンアルカロイド大環状二量体の化学構造と光学活性(口頭発表の部)
- ARAGUSPONGINES B, C, D, E, F, G, H, AND J, NEW VASODILATIVE BIS-1-OXAQUINOLIZIDINE ALKALOIDS FROM AN OKINAWAN MARINE SPONGE, XESTOSPONGIA SP.
- 14 海綿Dysidea arenaria由来の新規抗腫瘍性デプシペプチドArenastatin A(口頭発表の部)
- Marine Natural Products. X. Pharmacologically Active Glycolipids from the Okinawan Marine Sponge Phyllospongia foliascens (PALLAS)
- Foliaspongin, an Antiinflammatory Bishomosesterterpene from the Marine Sponge Phyllospongia foliascens (PALLAS)
- Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells
- P-226 NOVEL POLYKETIDES, SHIMALACTONES A AND B, FROM A MARINE-DERIVED FUNGUS EMERICELLA VARIECOLOR GF10
- P-98 CORTISTATINS A, B, C, AND D, ANTI-ANGIOGENIC STEROIDAL ALKALOIDS, FROM THE MARINE SPONGE CORTICIUM SIMPLEX
- P-63 SYNTHETIC STUDIES OF BASTADIN 6, AN ANTI-ANGIOGENIC SUBSTANCE FROM MARINE SPONGE
- Sesquiterpene Aminoquinones, from a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells
- Reversing Effect of Agosterol A, a Spongean Sterol Acetate, on Multidrug Resistance in Human Carcinoma Cells
- 各種甘草含有成分のHPLCによる定量分析
- 甘草修治における成分変化 : 皮去り甘草と炙甘草中のサポニン及びフラボノイド成分の定量分析
- 日本産アカヤジオウとカイケイジオウの交配種フクチヤマジオウ根の含有成分
- インドネシア薬用植物第XXI報 : Erythrina variegata樹皮とMaclura cochinchinensis根から単離したNa+/H+交換阻害物質
- インドネシア薬用植物 第XVIII報 : Koompassia malaccensis(マメ科)樹皮から単離した新規スチルベン-フェニルプロパノイド、Kompasonol A(発表論文抄録(1997))
- インドネシア薬用植物 第XVII報 : Quassia indica枝から単離したカッシノイド類の解析(発表論文抄録(1997))
- 74 ねじれたπ電子共役系の円二色性と絶対構造 : 天然物への応用
- HETEROSIGMA-GLYCOLIPIDS I AND II, TWO NEW GALACTOLIPIDS CONTAINING OCTADECATETRAENOYL AND EICOSAPENTAENOYL RESIDUES, FROM A RAPHIDOPHYTE DINOFLAGELLATE HETEROSIGMA SP.
- Marine Natural Products. XX. : Bioactive Scalarane-Type Bishomosesterterpenes from the Okinawan Marine Sponge Phyllospongia foliascens
- Marine Natural Products. XIX. : Pervicosides A, B, and C, Lanostane-Type Triterpene-Oligoglycoside Sulfates from the Sea Cucumber Holothuria pervicax
- Marine Natural Products. XVIII. : Four Lanostane-Type Triterpene Oligoglycosides, Bivittosides A, B, C, and D, from the Okinawan Sea Cucumber Bohadschia bivittata MITSUKURI
- Marine Natural Products. XVII. Nephtheoxydiol, a New Cytotoxic Hydroperoxy-Germacrane Sesquiterpene, and Related Sesquiterpenoids from an Okinawan Soft Coral of Nephthea sp. (Nephtheidae)(Organic,Chemical)
- Marine Natural Products. XVI. : Structures of Five New Diterpenes from an Okinawan Soft Coral of Xenia sp. (Xeniidae)
- KERICEMBRENOLIDES A, B, C, D, AND E, FIVE NEW CYTOTOXIC CEMBRENOLIDES FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
- Marine Natural Products. XIV. Structures of Echinosides A and B, Antifungal Lanostane-Oligosides from the Sea Cucumber Actinopyga echinites (JAEGER)
- XENIOLONE AND ISOXENIOLONE TWO NEW DITERPENES HAVING A PERHYDROAZULENE SKELETON FROM AN OKINAWAN SOFT CORAL OF XENIA SP.
- HALENAQUINOL AND HALENAQUINOL SULFATE, PENTACYCLIC HYDROQUINONES FROM THE OKINAWAN MARINE SPONGE XESTOSPONGIA SAPRA
- CLAVUKERIN C, A NEW TRINOR-GUAIANE SESQUITERPENE HAVING A HYDROPEROXY FUNCTION, FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
- 30 沖縄サンゴ礁生物Clavularia属軟サンゴ2種の成分研究
- Marine Natural Products. XII. On the Chemical Constituents of the Okinawan Marine Sponge Hymeniacidon aldis
- CLAVUKERIN A, A NEW TRINOR-GUAIANE SESQUITERPENE FROM THE OKINAWAN SOFT CORAL CLAVULARIA KOELLIKERI
- ABSOLUTE STEREOSTRUCTURES OF CLAVIRIDENONE-A, -B, -C, AND -D FOUR PROSTANOIDS FROM THE OKINAWAN SOFT CORAL CLAVULARIA VIRIDIS
- THREE NEW ent-VALERENANE SESQUITERPENES FROM AN OKINAWAN SOFT CORAL
- Marine Natural Products. IX. Structural Elucidation of Triterpenoidal Oligoglycosides from the Bahamean Sea Cucumber Actinopyga agassizi SELENKA
- The Structures of Six Antifungal Oligoglycosides, Stichlorosides A_1,A_2,B_1,B_2,C_1,and C_2,from the Sea Cucumber Stichopus Chloronotus (BRANDT)
- Marine Natural Products. VIII. Bioactive Triterpene-Oligoglycosides from the Sea Cucumber Holothuria leucospilota BRANDT (2). Structure of Holethurin A
- Marine Natural Products. VII. Bioactive Triterpene-Oligoglycosides from the Sea Cucumber Holothuria leucospilota BRANDT (1). Structure of Holothurin B
- Marine Natural Products. XXVI. Biologically Active Tridecapeptide Lactones from the Okinawan Marine Sponge Theonella swinhoei(Theonellidae).(2).Structures of Theonellapeptolides Ia, Ib, Ic, and Ie
- Direct Identification of a Novel Disulfide Bond Linkage System of New Isolated Isomer (Isomer V) in Recombinantly Produced h-IGF-I
- Synthesis of Two Possible Disulfide Bonds Containing Peptide Fragments(Cys^6-Cys^, Cys^-Cys^(Type I), and Cys^6-Cys^, Cys^-Cys^(Type II) of h-IGF-I) for the Identification of Disulfide Bond Linkage in Recombinantly Produced h-IGF-I
- Synthetic Studies on Biological Active Peptides 4 Synthesis of Two Possible Disulfide Bond-Containing Fragments,Cys6-Cys47,Cys48-Cys52(Type 1)and Cys6-Cys48,Cys47-Cys52(Type 2)of h-IGF-1(4-9,47-53),for the Chemical Identification of the Disulfide Bond Lin
- 海洋天然物 第XXXIII報 : 沖縄産海綿Theonella swinhoeiの産生する新規テトラデカペプチドラクトンTheonellapeptolide IId(発表論文抄録(1994))
- Marine Natural Products. XXXIII. Theonellapeptolide IId, a New Tridecapeptide Lactone from the Okinawan Marine Sponge Theonella swinhoei
- Formation and Hydrolysis of Enamine in Aqueous Solution
- Indonesian Medicinal Plants. XVII. Characterization of Quassinoids from the Stems of Quassia indica
- Marine Natural Products. XXXVI. Biologically Active Polyacetylenes, Adociacetylenes A, B, C, and D, from an Okinawan Marine Sponge of Adocia sp.
- Stichlorogenol and Dehydrostichlorogenol, Genuine Aglycones of Stichlorosides A_1,B_1,C_1 and A_2,B_2,C_2,from the Sea Cucumber Stichopus Chloronotus (BRANDT)
- インドネシア薬用植物 第VIII報 : Caesalpinia major(マメ科)根から単離した3種の新規カッサン型フラノジテルペンcaesaldekarin c, d,及びeの化学構造 : caesaldekarin aのN-ブロモスクシンイミド処理による数種の興味ある反応生成物(発表論文抄録(1997))
- THE ABSOLUTE STEREOSTRUCTURE OF ARENASTATIN A, A POTENT CYTOTOXIC DEPSIPEPTIDE FROM THE OKINAWAN MARINE SPONGE DYSIDEA ARENARIA
- IMPROVED TOTAL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF ARENASTATIN A, A POTENT CYTOTOXIC SPONGEAN DEPSIPEPTIDE
- P-56 海綿Dysidea arenaria由来の抗腫瘍性デプシペプチドarenastatin A : 類縁体合成と活性(ポスター発表の部)
- A TOTAL SYNTHESIS OF ARENASTATIN A, AN EXTREMELY POTENT CYTOTOXIC DEPSIPEPTIDE, FROM THE OKINAWAN MARINE SPONGE DYSIDEA ARENARIA
- Marine Natural Products. XXVII. Distribution of Lanostane-Type Triterpene Oligoglycosides in Ten Kinds of Okinawan Sea Cucumbers
- Marine Natural Products. XI. An Antiinflammatory Scalarane-type Bishomosesterterpene, Foliaspongin, from the Okinawan Marine Sponge Phyllospongia foliascens (PALLAS)
- Novel Neuronal Nitric Oxide Synthase(nNOS)Selective Inhibitor, Aplysinopsin-Type Indole Alkaloid, from Marine Sponge Hyrtios erecta
- Chemical Studies of Chinese Licorice-Roots. II. Five New Flavonoid Constituents from the Roots of Glycyrrhiza aspera PALL. Collected in Xinjiang
- Indonesian Medicinal Plants. XXI. Inhibitors of Na^+/H^+ Exchanger from the Bark of Erythrina variegata and the Roots of Maclura cochinchinensis
- インドネシア薬用植物 第XIV報 : Anthocephalus chinensis(アカネ科)樹皮から単離した新規セコイリドイド配糖体、3'-O-Caffeoylsweroside及び2種の新規フェノール性アピオグルコサイドKelampayoside A及びBの化学構造(発表論文抄録(1997))
- Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.
- Stereostructure of Komodoquinone A, a Neuritogenic Anthracycline, from Marine Streptomyces sp. KS3
- Marine Natural Products. XXXVIII. Absolute Stereostructures of Altohyrtins A, B, and C and 5-Desacetylaltohyrtin A, Potent Cytotoxic Macrolides, from the Okinawan Marine Sponge Hyrtios altum
- STRUCTURES OF SARASINOSIDES A_1, B_1, AND C_1 : NEW NORLANOSTANE-TRITERPENOID OLIGOGLYCOSIDES FROM THE PALAUAN MARINE SPONGE ASTEROPUS SARASINOSUM(Communications to the Editor)
- 75(PB2-5) パラオ産海綿Asteropus sarasinosumの産生するノルトリテルペンオリゴ配糖体sarasinoside類の化学構造(ポスター発表の部)
- TAXOL AND ITS RELATED TAXOIDS FROM THE NEEDLES OF TAXUS SUMATRANA
- インドネシア薬用植物 第VII報 : Peromema canescens(クマツヅラ科)葉から単離した7種の新規クレロダン型ジテルペン、ペロネミンA_2, A_3, B_1, B_2, B_3, C_1,及びD_1(発表論文抄録(1994))
- Indonesian Medicinal Plants. VII. Seven New Clerodane-Type Diterpenoids, Peronemins A_2,A_3,B_1,B_2,B_3,C_1,and D_1,from the Leaves of Peronema canescens (Verbenaceae)
- Marine Natural Products. XV. : Chemical Constituents of an Okinawan Soft Coral of Xenia sp. (Xeniidae)
- STRUCTURE OF THEONELLAPEPTOLIDE IE, A NEW TRIDECAPEPTIDE LACTONE FROM AN OKINAWAN MARINE SPONGE, THEONELLA SP. (THEONELLIDAE)(Communication to the Editor)
- Saponin and Sapogenol. XXVII. Revised Structures of Holotoxin A and Holotoxin B, Two Antifungal Oligoglycosides from the Sea Cucumber Stichopus japonicus SELENKA
- Application of Tumbling Melt Granulation (TMG) Method to Prepare Controlled-Release Fine Granules
- Application of Tumbling Melt Granulation Method to Prepare Controlled-Release Beads by Coating with Mixture of Functional Non-meltable and Meltable Materials
- 海綿由来の新規抗腫瘍物質の探索とその起源 : 海洋天然物化学の新展開で明かす海洋生物の謎 : シンポジウム(S-1)
- Taxus sumatrana葉から単離したタキソール及びその関連タキソイド類(発表論文抄録(1996))
- 海洋生物を起源とする制癌剤の探索
- 海洋生物成分の本
- 海洋生物由来の抗癌剤の探索
- 海洋天然物質の化学研究から
- 漢方薬・生薬認定薬剤師研修制度