Synthesis in the Diazasteroid Group. XVII. Syntheses of the 4,11-Diazasteroid System

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概要

• 論文の詳細を見る

• 5-(2-Oxocyclopentanecarboxamido) quinoline (IVb) was prepared from 5-aminoquinoline (IVa) and 2-carbethoxycyclopentanone (III) and isolated as a crystalline compound. IVb was treated with polyphosphoric acid-xylene to give 4,11-diazagona-1,3,5 (10), 6,8,13-hexaen-12-one (I). Two isomers, 4,11-diazagona-5,7,9,13-tetraen-12-one (II) and 1,2,3,4,7,8,9,10,11-nonahydro-4,11-diazacyclopenta [b] phenanthren-7-one (VI), were synthesized by the reaction of 1,2,3,4-tetrahydro-5-aminoquinoline (Va) and III in the presence of trifluoroacetic acid. 5-(2-Oxocyclopentanecarboxamido)-2-methoxyquinoline (X) could not be cyclized to the expected diazasteroid system under various conditions tested.

• 公益社団法人日本薬学会の論文
• 1981-03-25

著者

• 高畑 廣紀

  富山医科薬科大学薬学部

• 高畑 広紀

  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Osaka University

• 石上 英一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 高畑 広紀

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 山崎 高応

  富山医科薬科大学 薬

• 山崎 高応

  Faculty of Pharmaceutical Sciences

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