Synthesis of 8,10-Diaza-estrane

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概要

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• Reductive condensation of the amine (5) with the acid (2), followed by reduction of the carbonyl group and pyridine ring gave the cis-seco-8,10-diazasteroid (12). Reductive cyclization of 12 with lithium aluminum hydride afforded two configurational isomers (14a, b) of 8,10-diaza-estran. The stereochemistry of both isomers is discussed.

• 公益社団法人日本薬学会の論文
• 1980-03-25

著者

• 山崎 高應

  Faculty of Pharmaceutical Sciences, University of Toyama

• 永田 正典

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 高畑 廣紀

  富山医科薬科大学薬学部

• 山崎 高應

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 岡島 秀雄

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 高畑 広紀

  Toyama Medical and Pharmaceutical University

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