Ketene-S, N-acetals as Synthetic Intermediates for Heterocycles. Reaction of Ketene-S, N-acetals with Aryl Isocyanates

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概要

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• Reaction of ketene-S, N-acetals (1-6), which are useful synthetic intermediates for heterocycles, with aryl isocyanates (7) is described. Annulation of 1-3 and 4-6 with 7 in boiling toluene gave bicyclic (8-10) and monocyclic (11-13) uracil derivatives, respectively. Addition of 2,3,and 4 to 7 under mild conditions afforded the 1 : 1 adducts (18,19,and 21), respectively. Compounds 18 and 19 also reacted with 7 to give bicyclic uracil derivatives.

• 社団法人日本薬学会の論文
• 1985-10-25

著者

• 山崎 高應

  Faculty of Pharmaceutical Sciences, University of Toyama

• 山崎 高広

  富山医科薬科大学

• 高畑 廣紀

  富山医科薬科大学薬学部

• 山崎 高應

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 高畑 広紀

  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University

• 中島 智子

  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University

• 中野 正晴

  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University

• 冨口 明

  Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University

• 高畑 広紀

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 中野 正晴

  Research Institute Fuji Chemical Industries Ltd.

• 中島 智子

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 冨口 明

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

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