高選択的なヘテロ環化反応の開発と生物活性物質の合成への応用
スポンサーリンク
概要
- 論文の詳細を見る
Progress toward highly selective intramolecular heterocyclization and its application to the syntheses of biologically active compounds have been reviewed. The highly selective electrophilic heteroatom nucleophiles cyclization of carbon-carbon π-bonds such as iodoiminothiolactonization, iodolactamization, amidomercuration, iodolactonization, and oxylactonization has been developed. Our recent advances taking advantage of stereoselective heterocyclization of homochiral substrates readily available from optical active amine, the Katsuki-Sharpless oxidation, lipase-mediated transesterification, and α-amino acids have provided an attractive entry into the functionalized heterocycles as chiral building blocks. A promising approach to the chiral synthesis of a number of biologically active compounds such as alkaloids, antibiotics, and pheromones has emerged.
- 公益社団法人日本薬学会の論文
- 1993-11-25
著者
関連論文
- 薬理活性志向のヘテロ環の合成研究
- An Efficient Total Synthesis of (±)-Epilupinine and (±)-Lupinine from a Common Quinolizidine Intermediate
- Ketene-S, N-acetals as Synthetic Intermediates for Heterocycles. Reaction of Ketene-S, N-acetals with Aryl Isocyanates
- Synthesis in the Diazasteroid Group. XXI. An Alternative Synthesis of the 8,16-Diazasteroid System
- KETENE-S, N-ACETALS AS SYNTHETIC INTERMEDIATES FOR HETEROCYCLES. A NOVEL SYNTHESIS OF POLYFUNCTIONALIZED PYRIDINE-2-THIONES
- Activated Lactams. VI. The Cycloaddition Reaction of Cyclic Ketene-S, N-acetals with Dimethyl Acetylenedicarboxylate
- The Chemistry of Lactim Ethers. IV. Syntheses of 1,9-and 5,9-Diazasteroid Systems
- The Chemistry of Lactim Ethers. II. Reaction of Lactim Ethers with 2-Carbethoxymethyl Piperidines
- The Chemistry of Lactim Ethers. V. Reaction of Lactim Thioethers with β-Aminoesters
- A Convenient Synthesis of Monocyclic β-Lactams by Means of Solid-Liquid Phase Transfer Reactions
- Synthesis in the Diazasteroid Group. XV. Syntheses of the 5,9- and 8,13-Diazasteroids
- Synthesis in the Diazasteroid Group. XIV. Synthesis of the 13,15-Diazasteroid System
- Reaction of Lactim Thioethers with 1-Carbethoxymethyl-1,2,3,4-tetrahydroisoquinoline
- Synthesis of 8,10-Diaza-estrane
- Synthesis in the Diazasteroid Group. XVIII. Syntheses of the 9,17-Diazasteroid System
- Synthesis in the Diazasteroid Group. XVII. Syntheses of the 4,11-Diazasteroid System
- チオアミド官能基の特性を利用する複素環合成
- 二重不斉化反応による光学純度累進効果を活用する有機合成
- 非キラルなクロマトグラフィーにおける光学分割現象
- 高選択的なヘテロ環化反応の開発と生物活性物質の合成への応用
- 2級アリルアルコールに対する分子内アミノ付加反応を基盤とする含窒素生物活性物質のキラル合成