2級アリルアルコールに対する分子内アミノ付加反応を基盤とする含窒素生物活性物質のキラル合成
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概要
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The progress of the asymmetric syntheses of nitrogen-containing biologically active compounds such as pyrrolidine, pyrrolizidine, indolizidine alkaloids, and unusual amino acids has been reviewed. Our recent advances in taking advantage of stereoselective aminocyclization of homochiral N-alkenyl urethanes and thioimidates containing allylic hydroxyl group have provided an attractive entry into the functionalized pyrrolidine skeletones as chiral building blocks. A promising approach to a number of biologically active compounds such as alkaloids has emerged.
- 公益社団法人日本薬学会の論文
- 1992-04-25
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- 高選択的なヘテロ環化反応の開発と生物活性物質の合成への応用
- 2級アリルアルコールに対する分子内アミノ付加反応を基盤とする含窒素生物活性物質のキラル合成