KETENE-S, N-ACETALS AS SYNTHETIC INTERMEDIATES FOR HETEROCYCLES. A NOVEL SYNTHESIS OF POLYFUNCTIONALIZED PYRIDINE-2-THIONES
スポンサーリンク
概要
- 論文の詳細を見る
A new synthesis of polyfunctionalized pyridine-2-thiones (4a-c) by the carbon-carbon bond formation between β-aminothiocarbonyl-α-methylthioenamines (3a-c) derived from ketene-S, N-acetal (1) and malononitrile as a carbon nucleophile is described. In addition, the reaction of the dianiones (6a-c), prepared from the enaminonitriles (5a-c) and n-BuLi in situ, with alkyl halides (7,8,and 9) was found to give 3-alkylpyridine-2-thiones (10a-c, 11a-c, and 12a-c) in good yields, respectively.
- 社団法人日本薬学会の論文
- 1984-04-25
著者
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山崎 高應
Faculty of Pharmaceutical Sciences, University of Toyama
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山崎 高広
富山医科薬科大学
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高畑 廣紀
富山医科薬科大学薬学部
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山崎 高應
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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高畑 広紀
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University
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中島 智子
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University
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高畑 広紀
Faculty Of Pharmaceutical Sciences University Of Tokyo
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中島 智子
Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University
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