Synthesis in the Diazasteroid Group. XIX. Synthesis of the 9,13-Diazasteroid System
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概要
- 論文の詳細を見る
Quinoline N-oxide was treated with 1H-pyrrole in the presence of acetic anhydride to give 2-(2 [1H] pyrrolyl) quinoline (Ib) in 37.4% yield. In the reaction of Ib and 2-chloroethyl tosylate (V) in acetone catalyzed by potassium hydroxide, 2-(1-(2-tosyloxyethyl)-2 [1H]-pyrrolyl) quinoline (Ic) was obtained. Ic was unstable and cyclized gradually to a quaternary tosylate (VIa), which was reduced with sodium borohydride in methanol to 9,13-diazagona-1,3,5 (10), 14,16-pentaene (VII), which was identified as its picrolonate.
- 公益社団法人日本薬学会の論文
- 1982-05-25
著者
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山崎 高應
Faculty of Pharmaceutical Sciences, University of Toyama
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山崎 高應
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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的場 勝英
Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University
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的場 勝英
Faculty Of Pharmaceutical Sciences Osaka University
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柴田 美穂子
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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柴田 美穂子
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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