Synthesis in the Diazasteroid Group. IV. A Synthesis of 2,3-Dimethoxy-8,14-diaza-15-oxo-gona-1,3,5 (10)-triene

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概要

• 論文の詳細を見る

• 3,4-Dimethoxyphenethyl hydrazine (III), reacting with ethyl γ-oxopimelate, was converted into the hydrazone (IV), which was reduced to the corresponding hydrazine (V). V was then subjected to the intramolecular ring closure to afford (VI), which showed dimorphism. VI was subjected to the Bischler-Napieralski reaction accompanied with the reduction to afford the titled compound (VIII), which was also obtained by the Bischler-Napieralski ring closure of V followed by the reduction and the ring closure to furnish the D-ring of the diazasteroid. The stereochemistry of VIII was discussed based on its nuclear magnetic resonance data and its mercuric acetate oxidation.

• 公益社団法人日本薬学会の論文
• 1975-12-25

著者

• 永田 正典

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Osaka University

• 山崎 高応

  富山医科薬科大学 薬

• 山崎 高応

  Faculty of Pharmaceutical Sciences

• 宮越 寿美子

  Faculty of Pharmaceutical Sciences, University of Toyama

• 竹沢 弘

  Faculty of Pharmaceutical Sciences, University of Toyama

• 竹沢 弘

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 宮越 寿美子

  Faculty Of Pharmaceutical Sciences University Of Toyama

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