Michael Addition of [1H] Pyrrole

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概要

• 論文の詳細を見る

• [1H] Pyrrole (IIa) was reacted with 2-chloroethyl tosylate (III) in acetone in the presence of potassium hydroxide (condition A) to give 1-(4-oxo-2-methyl-2-pentyl) [1H]-pyrrole (IV) instead of 1-(2-tosyloxyethyl) [1H] pyrrole (IIb). IV was obtained from the reaction of IIa and mesityl oxide (V) in acetonitrile in the presence of potassium hydroxide (condition B). With IIa under condition B, crotononitrile, ethyl crotonate, and 4,4-dimethyl-2-cyclohexenone (IX) gave 3-(1-[1H] pyrrolyl) butyronitrile (VIIa), 3-(1-[1H] pyrrolyl) butyric acid (VIIIa), and a mixture of 4,4-dimethyl-3-(1-[1H] pyrrolyl) cyclohexanone (X) and 1-cyanomethyl-4,4-dimethyl-3-(1-[1H] pyrrolyl) cyclohexanol (XI), respectively.

• 公益社団法人日本薬学会の論文
• 1982-07-25

著者

• 山崎 高應

  Faculty of Pharmaceutical Sciences, University of Toyama

• 山崎 高應

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

• 的場 勝英

  Faculty Of Pharmaceutical Sciences Osaka University

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