酵母増殖のageに関する培養模型

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From the viewpoint of cell age which was introduced in this paper as shown in Fig. 1,some correlations were made between the age and the fermentation course in the case of yeast propagation (Eqns. 3,6,8 and 9).Assuming that each of the second terms of denominators in Eqns. 10 and 11 is negligible compared with the first terms and assuming further a symmetry of the course around the value of t_<(rn)m> regarding r_n and t as also shown in Fig. 1(a), the first terms in denominators of these equations must represent their maximum value, provided the nominators are maximum in values. Under the above-mentioned conditions, Eqn. 13 was derived from Fig. 1. The determination of cultural characteristics pertaining to single cells with Eqns. 10,11 and 13 is as follows. First, the values of θ_L, r_<w2>/r_<w1> and r_<s2>/r<_s1> are assumed to be given. Secondly, the values of θ_1 in Eqns. 10 and 11 were estimated from Eqn. 13. Lastly, using the experimental data concerning dX/dt and dS/dt in these equations, together with r_n, the calculations of r_<w1 >amd r_<s1> were repeated until the value of r_<w1> and r_<s1> were shown to become constant irrepectve of the fermentation time. In order to study the cultural characteritics of yeast cells with the above procedure, the cells were grown in a certain medium (composition : see Table 1) with a jar fermentor (volume : 5 liter).Final results are shown in Figures extending 11 to 14.
社団法人日本生物工学会の論文
1963-02-15

酵母増殖のageに関する培養模型

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