Apparent age による連続発酵の検討について(生物化学工学特集号-II 滅菌および培養工学)

概要

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Assuming that microbes suspended in each fraction of flowing cultural medium through equi-volume and non-equi-volume with completely mixed vessels, N in series, may undergo specific growth depending on each holding time, Eqs. (15) and (17)(apparent age distribution), Eqs. (7) and (18) (cell concentration), Eq. (9) (cell increase) and furthermore Eq. (10) (rate of cell increase) were obtained.Table 1 and a series of Equations extending from (23) to (27) were prepared in order to evaluate cell mass, substrate consumption and product formation in the case of continuous operation. This procedure is based on an assumption that an apparent age model in batch culture could be used as a convenient tool of studying some aspects of continuous culture. Using the published data of alcohol fermentation with molasses and glucose and streptomycin fermentation, tha fitness of the above-mentioned equations to practice was examined. As the result, Fig. 11 (growth) and both of Figs. 6,13 and Table 6 (sugar consumption and product formation) were obtained regarding the continuous culture. To recapitulate, it may be said that growth of microbes showed a considerable acceleration compared to the batch, while the batch did not make any significant difference from the continuous in terms of sugar consumption and product formation rate in the view point of apparent cell age.
社団法人日本生物工学会の論文
1965-08-25