微生物の炭化水素利用に関する研究 : (第10報) 炭化水素醗酵によるCandida tropicalis pK 233のCoenzyme Q生産 : (Part III) Coenzyme Q 生成に及ぼす呼吸系関連物質の影響

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This paper deals with the effects of compounds related to the mitochondrial respiratory system, employed in an attempt to enhance the coenzyme Q content of Candida tropicalis pK 233 in hydrocarbon fermentation. The compounds tested were the acids related to the TCA cycle, such as acetic, citric, succinic, fumaric, and malic; metal ions, such as Ca^<+2>, Fe^<+3> and Mg^<+2>; and riboflavin, Coenzyme Q production by the yeast was enhanced by supplementary addition of TCA-cycle acids and Ca^<+2> ion to the hydrocarbon medium at suitable concentrations. Addition of Fe^<+3> ion at a higher concentration was also effective, whereas the presence of high concentrations of Mg^<+2> and Ca^<+2> ions lowered the coenzyme production. Addition of an excess of riboflavin was not only ineffective but also rather inhibitory to coenzyme production. The effect of aeration was also investigated. About 12.8 mg/l-broth of coenzyme Q was produced by Candida tropicalis pK 233 under the conditions employed.
公益社団法人日本生物工学会の論文
1970-09-25