自然発症高血圧ラット(SHR)を用いた本みりんの血圧上昇抑制効果の検討

概要

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We investigated the antihypertensive effect of mirin intake on spontaneously hypertensive rats (SHRs). Mirin for the oral administration was concentrated at 90℃ to half the original amount. Ten male SHRs at 20 weeks of age were divided into two groups of five animals each : the test and control groups. Concentrated mirin at a dose of 7ml/kg was orally administered to each rat in the test group, while nothing was orally administered to the animals in the control group. The systolic blood pressure (SBP) and heart rate of each SHR in the two groups were measured before, and 3, 6 and 9hr after the single oral administration to the test animals. SBP of the test group animals 3, 6 and 9hr after the single oral administration was found to be significantly lower than that of the control group rats. However, there was no significant difference in the heart rate between animals in the two groups. The concentrated mirin therefore had a mildly reducing effect on the blood pressure, but no influence on the heart rate of SHRs.
2005-10-20