PRIMARY DERMAL AND EYE IRRITABILITY TESTS OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very slight erythema was observed in both skins and this polymer was categorized as a "mild irritant". In the eye irritation test, with a dispersion of the same concentration, it was categorized as "marginal" in unrinsed eyes and "negative" in rinsed eyes.
- 日本トキシコロジー学会の論文
- 1992-02-25
著者
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Tanaka O
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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Tanaka O
Department Of Biology Faculty Of Science And Engineering Konan University
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Tanaka O
Shimane Medical University
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Obara S
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
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Obara Sakae
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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ICHIKAWA Naoto
Bio-Medical Research Laboratories Co., Ltd.
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TANAKA Osamu
Bio-Medical Research Laboratories Co., Ltd.
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KAWANABE Mikiko
Bio-Medical Research Laboratories Co., Ltd.
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MUTO Hiroaki
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.
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KOKUBO Hiroyasu
Specialty Chemicals Research Center, Shin-Etsu Chemical Co.
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Ichikawa Naoto
Bio-medical Research Laboratories Co. Ltd.
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Muto H
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
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Muto Hiroaki
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Kokubo H
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
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Kawanabe Mikiko
Bio-medical Research Laboratories Co. Ltd.
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Kokubo Hiroyasu
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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