A THREE-MONTH REPEATED ORAL ADMINISTRATION STUDY OF A LOW VISCOSITY GRADE OF HYDROXYPROPYL METHYLCELLULOSE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The toxicity of the lowest viscosity grade of hydroxiprorpyl methylcellulose (HPMC) that is currently commercially available was investigated by means of a three-month repeated oral administration study in male and female Crj:CD (SD) IGS rats at doses of 505, 1,020 and 2,100 mg/kg/day. Body weights of males and females in the 2,100 mg/kg group were lower than those of the control group on and after day 28 of administration, but the differences were not statistically significant. The degree of suppression of body weight gain in males was higher than that in females. This tendency was similar to the results in other toxicity studies of HPMC that have been reported. Males in the 2,100 mg/kg group showed a tendency (not significant) for decreased food consumption and urine volume. Examinations of general signs, hematology, blood chemistry, ophthalmology, absolute and relative organ weights, autopsy and Phistopathology revealed only a few, apparently coincidental, statistically significant differences from the control, and no evidence of any dose-dependent changes was found. It was concluded that the lowest viscosity grade of HPMC showed extremely lo1w toxicity under the conditions of this study, as has been found for higher viscosity grades.
- 日本トキシコロジー学会の論文
著者
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Hirata Mariko
Safety Research Division Safety Research Institute For Chemical Compounds Co. Ltd
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Yoshida Ayako
Department Of Ophthalmology Kyushu University Graduate School Of Medicine
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SUNAGA Masao
Safety Research Division, Safety Research Institute for Chemical Compounds Co., Ltd.
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FURUKAWA Masatoshi
Safety Research Division, Safety Research Institute for Chemical Compounds Co., Ltd.
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Yoshida A
Department Of Ophthalmology Kyushu University Graduate School Of Medicine
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Obara Sakae
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Sunaga Masao
Safety Research Institute For Chemical Compounds Co. Ltd.
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MUTO Hiroaki
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.
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SHIGENO Hitoshi
Safety Research Institute for Chemical Compounds Co.,Ltd.
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YOSHIDA Ayako
Safety Research Institute for Chemical Compounds Co.,Ltd.
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NAGAYA Jyun-ichi
Safety Research Institute for Chemical Compounds Co.,Ltd.
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Muto Hiroaki
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
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Hirata Mariko
Safety Res. Inst. Chemical Compounds Co. Ltd Hokkaido Jpn
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Furukawa Masatoshi
Safety Research Division Safety Research Institute For Chemical Compounds Co. Ltd.
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Furukawa Masatoshi
Safety Research Institute For Chemical Compounds Co. Ltd.
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Nagaya Jyun-ichi
Safety Research Institute For Chemical Compounds Co. Ltd.
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Shigeno Hitoshi
Safety Research Institute For Chemical Compounds Co. Ltd.
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Furukawa Masatoshi
Safety Res. Inst. For Chemical Compounds Co. Ltd.
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