HIGHER SUSCEPTIBILITY OF NEWBORN THAN YOUNG RATS TO 3-METHYLPHENOL
スポンサーリンク
概要
- 論文の詳細を見る
To determine susceptibility of infants to 3-methylphenol, a repeated dose toxicity study was conducted with oral administration to newborn and young rats. In an 18-day newborn study from postnatal days 4 to 21 at doses of 30, 100 and 300 mg/kg/day, various clinical signs including deep respiration, hypersensitivity on handling and tremors under contact stimulus, and depressed body weight gain were observed at 300 mg/kg. At 100 mg/kg, hypersensitivity and tremors were also noted in a small number of males only on single days during the dosing period. No adverse effects were observed in the 30 mg/kg group. There were no abnormalities of physical development, sexual maturation and reflex ontogeny. The no observed adverse effect level (NOAEL) for newborn rats was considered to be 30 mg/kg/day and the unequivocally toxic level 300 mg/kg/day. In a 28-day study starting at 5 weeks of age, clinical signs and depression of body weight gain, as observed in the newborn rats, appeared in both sexes at 1000 mg/kg but not 300 mg/kg. The NOAEL and the unequivocally toxic level were 300 mg/kg/day and 1,000 mg/kg/day, respectively. From these results, newborn rats were concluded to be 3 to 10 times more susceptible to 3-methylphenol than young rats. However, the realistic no adverse effect dose for the newborn must be slightly lower than 100 mg/kg/day, at which the toxicity incidence was very low, rather than 30 mg/kg/day. Based on this speculation and the equal toxicity at unequivocally toxic levels, the differences in the susceptibility to 3-methylphenol could be concluded to be 3 to 4 times. This is consistent with the results of our previous comparative studies on 4-nitrophenol, 2,4-dinitrophenol and 3-aminophenol, which showed 2 to 4 times differences in the susceptibility between newborn and young rats.
- 日本トキシコロジー学会の論文
- 2003-05-31
著者
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KAMATA Eiichi
National Institute of Health Sciences
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Hasegawa Ryuichi
ボゾリサーチセンター
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Hasegawa Ryuichi
National Institute Of Health Sciences
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Hasegawa Ryuichi
Division Of Toxicology National Institute Of Health Sciences
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Furukawa Masakazu
Institute Of Biological Science Mitsui Pharmaceuticals
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Ito Yoshihiko
Research Institute For Animal Science In Biochemistry And Toxicology
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Fujii Sakiko
Safety Research Division Safety Research Institute For Chemical Compounds Co. Ltd
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Fujii Sakiko
Safety Research Institute For Chemical Compounds Co. Ltd.
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Kamata E
National Institute Of Health Sciences
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NODA Atsushi
Research Institute for Animal Science in Biochemistry and Toxicology
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Noda Atsushi
Marine Geology Department Geological Survey Of Japan
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FURUKAWA Masatoshi
Safety Research Division, Safety Research Institute for Chemical Compounds Co., Ltd.
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Ema Makoto
National Institute of Health Sciences, Osaka Branch
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KOIZUMI Mutsuko
National Institute of Health Sciences
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ITOH Yoshihiko
Research Institute for Animal Science in Biochemistry and Toxicology
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Kamata Eiichi
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Hasegawa Ryuich
Division Of Toxicology National Institute Of Health Sciences
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Hasegawa Ryuichi
Division Of Medical Safety Science
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Hasegawa Ryuichi
Department Of Intensive Care Medicine Tohoku University Hospital
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Furukawa M
Safety Research Institute For Chemical Compounds Co. Ltd.
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Ema M
National Institute Of Health Sciences
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Ema Makoto
National Institute Of Health Sciences Osaka Branch
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Ema Makoto
National Institute Of Hygienic Sciences Osaka Branch
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Kamata Eiichi
National Institute Of Hygienic Sciences
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Koizumi Mutsuko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Koizumi Mutsuko
Division Of Medicinal Safety Science National Institute Of Health Sciences
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Kamata Eiichi
National Inst. Of Health Sciences (nihs)
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Furukawa Masatoshi
Safety Research Division Safety Research Institute For Chemical Compounds Co. Ltd.
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Ema Makoto
National Institute Of Health Sciences
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Furukawa Masatoshi
Safety Res. Inst. For Chemical Compounds Co. Ltd.
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Fujii Sakiko
Safety Res. Inst. For Chemical Compounds Co. Ltd.
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Koizumi Mutsuko
Division Of Risk Assessment National Institute Of Health Sciences
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Koizumi Mutsuko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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Hirata Koizumi
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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