ANTIPYRETIC EFFECT OF INDOMETHACIN SUPPOSITORY IN RABBITS
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概要
- 論文の詳細を見る
We have designed a thermistor rectal probe thermometer for measuring the antipyretic activity of suppositories. Using this thermistor probe, we tested the antipyretic effect of an indomethacin suppository in comparison with oral and intravenous administrations in rabbits (male, 2.5-2.9 kg). The rectal temperature of normal rabbits remained unchanged after rectal and intravenous administration of indomethacin, 25 mg/body and 10 mg/kg, respectively. The antipyretic effect was tested in febrile rabbits injected with bacterial pyrogen, lipopolysaccharide (LPS) 0.2 μg/kg (i.v.). The dose-dependent antipyretic activities were observed in febrile rabbits administered with indomethacin by rectal (6.3-23.7 mg/body), intravenous (2.5-10 mg/kg) and oral (2.5-20 mg/kg) routes. When indomethacin was administered simultaneously or 1 h after LPS, the most potent antipyretic effect was observed in the case of rectal administration and the weakest effect was observed in that of oral administration. These data indicate that the rectal administration of drugs can produce a potent antipyretic activity, not inferior to that of the intravenous injection.
- 公益社団法人日本薬学会の論文
著者
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Ema Makoto
National Institute of Health Sciences, Osaka Branch
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Kanoh S
National Institute Of Hygienic Sciences Osaka Branch
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Kanoh Seizaburo
National Institute Of Hygienic Sciences Osaka Branch
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Ema M
National Institute Of Health Sciences
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Ema Makoto
National Institute Of Health Sciences Osaka Branch
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Ema Makoto
National Institute Of Hygienic Sciences Osaka Branch
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Itami Takafumi
National Institute Of Hygienic Sciences Osaka Branch
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Ema Makoto
National Institute Of Health Sciences
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