STUDIES ON SINGLE-DOSE TOXICITY OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Single-dose toxicological studies of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether) were conducted. A dispersion of HM-HPMC was administered to rats orally or by dermal application at doses up to 900 mg/kg. After the oral administration, the mean body weight of the 900 mg/kg group on the first day after administration was slightly but significantly lower (P<0.05) than that of the control group, and one rat had loose stools at 30 min. after the administration. No other abnormalities were noted. In the case of dermal application, no abnormalities were observed. No rats died, and no abnormalities in their organs were found by either route. In conclusion, there was no observed toxicity of HM-HPMC after oral or dermal administration at single dose up to 900 mg/kg under the conditions of these studies.
- 日本トキシコロジー学会の論文
- 1992-02-25
著者
-
Tanaka O
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
-
Tanaka O
Department Of Biology Faculty Of Science And Engineering Konan University
-
Tanaka O
Shimane Medical University
-
Obara S
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
-
Obara Sakae
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
-
ICHIKAWA Naoto
Bio-Medical Research Laboratories Co., Ltd.
-
TANAKA Osamu
Bio-Medical Research Laboratories Co., Ltd.
-
KAWANABE Mikiko
Bio-Medical Research Laboratories Co., Ltd.
-
MUTO Hiroaki
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd.
-
KOKUBO Hiroyasu
Specialty Chemicals Research Center, Shin-Etsu Chemical Co.
-
Ichikawa Naoto
Bio-medical Research Laboratories Co. Ltd.
-
Muto H
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
-
Muto Hiroaki
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
-
Kokubo H
Shin‐etsu Chemical Co. Ltd. Niigata Jpn
-
Kawanabe Mikiko
Bio-medical Research Laboratories Co. Ltd.
-
Kokubo Hiroyasu
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
関連論文
- 高周波スパッタリングによるMgO薄膜の配向性と微細構造(セラミックスの微細構造)
- Identification of reaction products of 9-hydroxy-10-oxo-12(Z), 15(Z)-octadecadienoic acid (KODA) and norepinephrine that strongly induce flowering in Lemna
- HIPを利用した高密度ペロブスカイトLaNiO_3の作製
- プラズマCVD法による硬質アモルファス窒化ホウ素膜の作製
- アセチルアセトンによるZn0膜のエッチング
- プラズマCVD法によるSiN_xC_y膜の熱的安定性
- 反応性スパッタリングによるSiC_x膜の機械的性質
- プラズマCVD-SiNxCy膜のEPMAによる組成分析
- HIPによる金属表面上へのセラミックスコーティング
- 718 HIP による金属表面上へのセラミックスコーティング(セラミックス : 焼結, 破壊特性, 被覆, 萌芽・境界技術, 日本鉄鋼協会第 114 回(秋季)講演大会)
- Sweet Cucurbitane Glycosides from Fruits of Siraitia siamensis (chi-zi luo-han-guo), a Chinese Folk Medicine(Organic Chemistry)
- PC76 SOLUBILIZATION OF SAIKOSAPONIN-a AND α-TOCOPHEROL WITH PLANT GLYCOSIDES
- RETICULOENDOTHELIAL SYSTEM ACTIVATING POLYSACCHARIDES FROM Panax SPP : P. notoginseng, P. ginseng and P. japonicus
- Saponins of Plants of Panax Species Collected in Central Nepal, and Their Chemotaxonomical Significance. III.
- Bioactive Saponins and Glycosides. XI. Structures of New Dammarane-Type Triterpene Oligoglycosides, Quinquenosides I, II, III, IV, and V, from American Ginseng, the Roots of Panax quinquefolium L.
- Bioactive Saponins and Glycosides. IX. Notoginseng (2) : Structures of Five New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-E, -G, -H, -I, and -J, and a Novel Acetylenic Fatty Acid Glycoside, Notoginsenic Acid β-Sophoroside, from the Dried
- Bioactive Saponins and Glycosides. VIII. Notoginseng (1) : New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-A, -B, -C, and -D, from the Dried Root of Panax notoginseng (BURK.) F. H. CHEN
- TiN-TiB_2系常圧焼結体の機械的及び電気的特性
- プラズマ CVD 法による Si_3N_4-SiC 系薄膜の直流電気伝導特性
- 各種焼結助剤添加ホットプレスTiNセラミックスの機械的特性
- ECRプラズマCVD法による硬質炭素膜の合成 (超薄膜--その機能と制御)
- ECR型プラズマCVD法により合成された炭素薄膜の表面組織とプラズマ発光スペクトル強度
- ホットプレス法による窒化チタンセラミックスの強度及び電気的特性
- ホットプレス法によるTiNセラミックスの特性--焼結助剤添加の影響
- 高周波プラズマCVD法による炭素膜へのバイアス効果
- アセチルアセトンによるMgO薄膜のエッチング
- Effects of Spaceflight on Enzyme Activities and Ultrastructure of Fast-Type Skeletal Muscles of Rats
- A-band Movement and Junctional Gap Dissociation during Caffeine-induced Contracture of Skeletal Muscle Fibers
- Study on Improvement of Sweetness of Steviol Bisglycosides: Selective Enzymic Transglucosylation of the 13-O-Glycosyl Moiety
- Effect of Several Cellulosic Binders on Particle Size Distribution of Granules Prepared by a High-Speed Mixer
- Substrate Specificity of Glycyrrhizinic Acid Hydrolase(Organic Chemistry)
- Morphological analysis of neural tube defects : Chlorambucil-induced exencephaly in mice
- Identification and Quantification of 20(S)-Protopanaxatriol and its 20S, 24S-Epoxide in Human Urine with the Treatment of A1kaline Cleavage after the Ingestion of Sanchi Ginseng, the Roots of Panax notoginseng(三七人参)
- Antimicrobial Activities of Saponins of Pericarps of Sapindus mukurossi on Dermatophytes
- Inhibition of Aldose Reductase and Sorbitol Accumulation by Astilbin and Taxifolin Dihydroflavonols in Engelhardtia chrysolepis
- Studies of the Constituents of Astragalus membranaceus BUNGE. III. Structure of Triterpenoidal Glycosides, Huangqiyenins A and B, from the Leaves
- Protection against Oxidative Damage by Dihydroflavonols in Engelhardtia chrysolepis
- Sweetness of Glycyrrhetic Acid 3-O-β-D-Monoglucuronide and the Related Glycosides
- Enzymic Production of Sweet Stevioside Derivatives : Transglucosylation by Glucosidases(Organic Chemistry)
- Further Study on the 1,4-α-Transglucosylation of Rubusoside, a Sweet Steviol-Bisglucoside from Rubus suavissimus(Organic Chemistry)
- Production of Stevioside and Rubusoside Derivatives by Transfructosylation of β-Fructofuranosidase(Biological Chemistry)
- Chemical Studies on Fuku-bon-shi : a Dimer of Glucosyl Esters of 19α-Hydroxyursolic Acid Derivatives from Rubus coreanus and its Significance for Identification of the Source Plants
- Production of Rubusoside Derivatives by Transgalactosylation of Various α-Galactosidases(Biological Chemistry)
- Production of Rubusoside Derivatives by Transgalactosylation of Various β-Galactosidases(Biological Chemistry)
- Enzymic Transglucosylation Products of Stevioside: Separation and Sweetness-evaluation(Food & Nutrition)
- BIOLOGICALLY ACTIVE POLYSACCHARIDE FROM SANCHIGINSENG, ROOTS OF PANAX NOTOGINSENG
- Rubusoside (β-D-Glucosyl Ester of 13-O-β-D-Glucosyl-steviol), a Sweet Principle of Rubus chingii Hu (Rosaceae)
- レーザーCVDによるTiO_2膜の合成
- Isolation of Protoplast from Aerial Mycelia and Fruit-Body Formation from Regenerated Mycelia in Pleurotus cornucopiae
- Improvement of the Aluminum Borate Whisker-Mediated Method of DNA Delivery into Rice Callus(Cell and Molecular Biology)
- Plant regeneration in Actinidia polygama Miq. by leaf, stem, and petiole culture with zeatin, and from stem-derived calli on low-sucrose medium
- Varietal Differences in the Morphophysiological Response to Atmospheric Humidity in Rice
- Studies on the Effect of the Relative Humidity of the Atmosphere on the Growth and Physiology of Rice Plants : Effects of relative humidity during the light and dark periods on the growth
- Aluminium Borate Whisker-Mediated DNA Delivery into Callus of Rice and Production of Transgenic Rice Plant
- Inhibition of Flower Induction by Some Inhibitors of Protease in the Short-day Plant Lemna paucicostata 6746 and the Long-day Plant Lemna gibba G3
- Comparison between Induction of Flowering by Nitrogen Deficiency and that by Short Days or Continuous Irradiation with Blue or Low-Intensity White Light in Lemna paucicostata 6746
- プラズマCVD法によるSi_3N_4-SiC系非晶質膜の軽イオンビーム照射損傷
- Effects of Exogenous Amino Acids on Iron Uptake in Relation to their Effects on Photoperiodic Flowering in Lemna paucicostata 6746
- Measurement of Endogenous Phosphorus Levels in Relation to Flowering in the Long-Day Plant Lemna gibba G3
- プラズマCVD法によるSi_3N_4-SiC系セラミックス薄膜の合成
- Flower Induction by Suppression of Nitrate Assimilation in Lemna paucicostata 6746
- PHOTOPERIODIC FLOWERING OF CUSCUTAJAPONICA
- Photoperiodic Flowering of Cuscuta japonica Cultured In Vitro
- Identification of a Component that Induces Flowering of Lemna among the Reaction Products of α-Ketol Linolenic Acid (FIF) and Norepinephrine
- CHEMICAL STRUCTURE OF THE MAJOR COMPONENTS OF REACTANTS BETWEEN FIF AND NOREPINEPHRINE WHICH STRONGLY INDUCE FLOWER FORMATION OF LEMNA
- Development of Cellulose Derivatives as Novel Enteric Coating Agents Soluble at pH 3.5-4.5 and Higher
- Morphological Changes of Unmyelinated Nerves in the Cerebral Arteries after Removal of the Pterygopalatine Ganglion : An Electron Microscopic Study
- Morphological Analysis of Neural Tube Defects in Non-obese Diabetic (NOD) Mouse Embryos
- EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS
- TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS
- TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
- STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
- Flowering Induced by Nitrogen Deficiency in Lemna paucicostata 151
- Transgenic Plant Regeneration Through Silicon Carbide Whisker-Mediated Transformation of Rice (Oryza sativa L.)
- SKIN SENSITIZATION AND PHOTOSENSITIZATION STUDIES OF HYDROPHOBICALLY MODIFIED HYDROXYPRORYL METHYLCELLULOSE IN GUINEA PIGS
- A REPEATED-DOSE DERMAL TOXICITY STUDY OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RATS
- Innervation of human developing extraocular muscles : immunohistochemical study
- Primordial Formation of Fruit-body in Favolus arcularius induced by Distilled-Water Culture in Complete Darkness
- PRIMARY DERMAL AND EYE IRRITABILITY TESTS OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RABBITS
- STUDIES ON SINGLE-DOSE TOXICITY OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RATS
- Immunohistochemical Study on the Extraocular Muscles in Human Embryos
- A THREE-MONTH REPEATED ORAL ADMINISTRATION STUDY OF A LOW VISCOSITY GRADE OF HYDROXYPROPYL METHYLCELLULOSE IN RATS
- Effect of Several Cellulosic Binders and Method of Their Addition on the Properties and Binder Distribution of Granules Prepared in an Agitating Fluidized Bed
- Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared by a High-Speed Mixer
- Flower-Inducing Activity of Lysine in Lemna paucicostata 6746
- Flower-Inducing Activity of Exogenous Lysine in Lemna paucicostata 151 Cultured on Nitrogen-Rich Medium : GROWTH AND DEVELOPMENT
- Lysine Reverses the Inhibition of Flowering by Elastatinal, a Protease Inhibitor, in Lemna paucicostata 151
- Flower-Inducing Activity of Lysine in Lemna paucicostata 151 Cultured on Nitrogen-Deficient Medium : GROWTH AND DEVELOPMENT : PROTEINS, ENZYMES AND METABOLISM
- In vivo analysis of RGD-sequence dependent cortical histogenesis in mouse telencephalon
- Effects of Chlorambucil on the Brain Development in Mice during Post-neurulation Period
- プラズマCVD法によるアモルファス炭・窒化物膜
- 低温プラズマCVDによる炭・窒化物膜の合成 (セラミックスへのプラズマ利用)
- CYTOCHEMISTRY OF CA^-ATPASE ACTIVITY IN THE RAT SPINAL CORD DURING EMBRYONIC DEVELOPMENT
- Application of Extremely Low Viscosity Methylcellulose (MC) for Pellet Film Coating
- Molecular Weight Determination of Hypromellose Phthalate (HPMCP) Using Size Exclusion Chromatography with a Multi-angle Laser Light Scattering Detector
- Identification and Quantification of 20(S)-Protopanaxatriol and its 20S, 24S-Epoxide in Human Urine with the Treatment of A1kaline Cleavage after the Ingestion of Sanchi Ginseng, the Roots of Panax notoginseng(三七人参)
- Antimicrobial Activities of Saponins of Pericarps of Sapindus mukurossi on Dermatophytes
- 軽イオンビ-ム照射したステンレス鋼のEPMAによる組成分析
- ホットプレス法によるTiNセラミックスの特性--焼結助剤添加の影響
- セラミックスコ-ティングによる基体の強化