A-band Movement and Junctional Gap Dissociation during Caffeine-induced Contracture of Skeletal Muscle Fibers
スポンサーリンク
概要
- 論文の詳細を見る
The action of caffeine on the myofibril profile of the sarcomere and the junctional gap of the intracellular membrane was studied ultrastructurally. When a high concentration of caffeine (5mM) was applied, the movement of the A-band in sarcomeres dissected from the central portion of single muscle fibers was greater than that in sarcomeres dissected from the proximal and distal portions of the fiber. The amount of calcium released from the sarcoplasmic reticulum of the caffeine-treated muscle was greater in the terminal cisternae located on the narrow I band than in the wide I band, as determined by electron-probe analysis of ultrathin cryosections. The junctional gap was clearly expanded after caffeine treatment, resulting in an irreversible change in muscle contractility. These structural alterations may lead to the distinctive development of tension induced by caffeine. The expansion of the gap may also cause excitation-contraction uncoupling.
- 東海大学の論文
著者
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TANAKA Osamu
Department of Biology, Faculty of Science and Engineering, Konan University
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Tanaka O
Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University
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Yamashita-goto Katsumasa
鹿屋体育大学
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Yamashita-goto Katsumasa
Department Of Physiology Ii St. Marianna University School Of Medicine
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Yoshioka Toshitada
Department Of Physiology And Biomechanics National Institute Of Fitness And Sports
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Yoshioka T
Department Of Physiology School Of Medicine Tokai University
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SHIROTA Takuhiko
Department of Physiology, St. Marianna University School of Medicine
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TAZOE Takashi
Department of Physiology, St. Marianna University School of Medicine
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KIMURA Mizuo
Department of Physiology, St. Marianna University School of Medicine
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Kimura M
Department Of Physiology St. Marianna University School Of Medicine
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Yoshinaga Tomoo
鹿屋体育大学
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Tazoe Takashi
Department Of Physiology St. Marianna University School Of Medicine
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Kimura Mizuo
Department Of Physiology St. Marianna University School Of Medicine
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Mikio Kimura
Department Of Pediatrics School Of Medicine Tokai University
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Shirota Takuhiko
Department Of Physiology St. Marianna University School Of Medicine
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Tanaka O
Department Of Biology Faculty Of Science And Engineering Konan University
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Tanaka O
Shimane Medical University
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Tanaka Osamu
Department Of Anatomy Shimane Medical University
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Tazoe T
St. Marianna Univ. School Of Medicine Kawasaki Jpn
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Tanaka O
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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