Effect of Several Cellulosic Binders and Method of Their Addition on the Properties and Binder Distribution of Granules Prepared in an Agitating Fluidized Bed
スポンサーリンク
概要
- 論文の詳細を見る
A model system consisting of lactose-cornstarch was used to examine the effect of five cellulosic binders [hydroxypropylcellulose (HPC)(6cP), hydroxypropylmethylcellulose 2910 (HPMC)(3,6,15cP) and methylcellulose (MC)(15cP)] on the particle size distribution of granules prepared in an agitating fluidized bed under fixed operating conditions. The distribution of binder in different size fractions of granules was also determined by measuring the contents of methoxyl and hydroxypropoxyl groups. When the binders were added by the solution method, higher solution viscosity resulted in the granule size being increased, with almost equivalent binder distributions in different size fractions. The granules prepared by the dry mixing method with HPC (6cP) or HPMC (3cP) also showed a good correlation between median particle size and binder level, though the binders were concentrated in the coarse-sized particle fractions of the granules. The results are consistent with our previous findings on wet granulation with a fluidized bed. When a trace amount of water-soluble dye was mixed with the granulating liquid or powder components to examine the granulation mechanism in both the solution and the dry mixing methods of binder addition, the dye distributions were more uniform than the binder distributions, especially in the dry mixing method. This suggests that the solubility of binders or dye in water is a critical factor determining their distribution in the different size fractions of the granules.
- 1998-03-15
著者
-
KOKUBO Hiroyasu
Specialty Chemicals Research Center, Shin-Etsu Chemical Co.
-
Sunada Hisakazu
Faculty Of Pharmacy Meijo University
-
NAKASHIMA Chinatsu
Faculty of Pharmacy, Meijo University
-
Kokubo Hiroyasu
Specialty Chemicals Research Center Shin-etsu Chemical Co. Ltd.
関連論文
- Preparation of Rapidly Disintegrating Tablets Containing Itraconazole Solid Dispersions
- Rapidly Disintegrating Tablets Prepared by a Surface-Modifying Method : Comparison of Disintegrants
- Preparation and Evaluation of Solid Dispersions of Nitrendipine Prepared with Fine Silica Particles Using the Melt-Mixing Method
- Preparation and Evaluation of Solid Dispersion for Nitrendipine-Carbopol and Nitrendipine-HPMCP Systems Using a Twin Screw Extruder
- Evaluation of Bitterness Suppression of Macrolide Dry Syrups by Jellies
- Development of Cellulose Derivatives as Novel Enteric Coating Agents Soluble at pH 3.5-4.5 and Higher
- Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity
- Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules V. : Release Properties of Ethylcellulose Layered Matrix Granules
- Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems
- Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules III. Effects of the Dissolution Condition on the Release Process
- Analysis of the Release Process of Phenylropanolamine Hydrochloride from Ethylcellulose Matrix Granules II. Effects of the Binder Solution on the Release Process
- Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules
- Preparation of Solid Dispersion for Ethenzamide-Carbopol and Theophylline-Carbopol Systems Using a Twin Screw Extruder
- PRIMARY DERMAL AND EYE IRRITABILITY TESTS OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RABBITS
- STUDIES ON SINGLE-DOSE TOXICITY OF HYDROPHOBICALLY MODIFIED HYDROXYPROPYL METHYLCELLULOSE IN RATS
- Improvement of the Dissolution Rate of Nitrendipine Using a New Pulse Combustion Drying Method
- Effect of Several Cellulosic Binders and Method of Their Addition on the Properties and Binder Distribution of Granules Prepared in an Agitating Fluidized Bed
- Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared by a High-Speed Mixer
- Preparation and Evaluation of Combination Tablet Containing Incompatible Active Ingredients
- Release from or through a Wax Matrix System. IV. Generalized Expression of the Release Process for a Reservoir Device Tablet
- Release from or through a Wax Matrix System. III. Basic Properties of Release through the Wax Matrix Layer
- Release from or through a Wax Matrix System. II.^ Basic Properties of Release from or through the Wax Matrix Layer
- Dissolution of Solid Dosage Form. VII. Effect of Shape on the Dissolution of Nondisintegrating Single Component Tablet under Non-sink Condition
- Sustained-Release Progesterone Vaginal Suppositories 1 : Development of Sustained-Release Granule(Biopharmacy)
- Influence of Physicochemical Properties on Drug Release Rate from Hydroxypropylmethylcellulose Matrix Tablets
- Influence of Water-Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers
- Preparation and Evaluation of Ibuprofen Solid Dispersion Systems with Kollidon Particles Using a Pulse Combustion Dryer System
- Some Factors Influencing the Dissolution of Solid Dispersions with Nicotinamide and Hydroxypropylmethylcellulose as Combined Carriers
- Effect of Process Variables on the Properties and Binder Distribution of Granules Prepared in a Fluidized Bed
- Application of Extremely Low Viscosity Methylcellulose (MC) for Pellet Film Coating
- Release from or through a Wax Matrix System VI. : Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet
- Release from or through a Wax Matrix System. V. Applicability of the Square-Root Time Law Equation for Release from a Wax Matrix Tablet
- Release from or through a Wax Matrix System.I. Basic Release Properties of the Wax Matrix System
- Mechanistic Studies on Hydrotropic Solubilization of Nifedipine in Nicotinamide Solution
- Indomethacin Controlled Release Matrix Tablet Prepared by Wet Granulation Procedure
- Comparison of Nicotinamide, Ethylurea and Polyethylene Glycol as Carriers for Nifedipine Solid Dispersion Systems