Analysis of the Release Process of Phenylpropanolamine Hydrochloride from Ethylcellulose Matrix Granules IV. Evaluation of the Controlled Release Properties for in Vivo and in Vitro Release Systems
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概要
- 論文の詳細を見る
In the pharmaceutical preparation of a controlled release drug, it is very important and necessary to understand the release properties. The dissolution test is a very important and useful method for understanding and predicting drug-release properties. It was readily confirmed in the previous paper that the release process could be assessed quantitatively by a combination of the square-root time law and cube-root law equations for ethylcellulose (EC) matrix granules of phenylpropanolamine hydrochloride (PPA). In this paper EC layered granules were used in addition to EC matrix. The relationship between release property and the concentration of PPA in plasma after administration using beagle dogs were examined. Then it was confirmed that the correlativity for EC layered granules and EC matrix were similar each other. Therefore, it was considered that the dissolution test is useful for prediction of changes in concentration of PPA in the blood with time. And it was suggested that EC layered granules were suitable as a controlled release system as well as EC matrix.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Fujii R
Pharmaceutical Discovery Research Division Takeda Chemical Industries Ltd.
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SUNADA Hisakazu
Faculty of Pharmacy, Meijo University
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FUKUI Atsuko
Ryukakusan Co., Ltd.
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FUJII Ryuta
Ryukakusan Co., Ltd.
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YONEZAWA Yorinobu
Faculty of Pharmacy, Meijo University
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Fujii R
Ryukakusan Co. Ltd.
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Fukui Atsuko
Ryukakusan Co. Ltd.
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Yonezawa Y
Faculty Of Pharmacy Meijo University
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Yonezawa Yorinobu
Faculty Of Pharmaceutical Sciences Meijio University
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Sunada H
Faculty Of Pharmacy Meijo University
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Sunada Hisakazu
Fac. Of Pharmacy Meijo Univ.
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Sunada Hisakazu
Faculty Of Pharmacy Meijo University
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