Release from or through a Wax Matrix System VI. : Analysis and Prediction of the Entire Release Process of the Wax Matrix Tablet

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概要

• 論文の詳細を見る

• Analysis of the entire release process of the wax matrix tablet was examined. Wax matrix tablet was prepared from a physical mixture of drug and wax powder to obtain basic or clear release properties. The release process began to deviate from Higuchi equation when the released amount reached at around the half of the initial drug amount. Simulated release amount increase infinitely when the Higuchi equation was applied. Then, the Higuchi equation was modified to estimate the release process of the wax matrix tablet. The modified Higuchi equation was named as the H-my equation. Release process was well treated by the H-my equation. Release process simulated by the H-my equation fitted well with the measured entire release process. Also, release properties from and through wax matrix well coincident each other. Furthermore, it is possible to predict an optional release process when the amount of matrix and composition of matrix system were defined.

• 公益社団法人日本薬学会の論文
• 2005-08-01

著者

• YONEZAWA Yorinobu

  Faculty of Pharmacy, Meijo University

• Ishida S

  Faculty Of Pharmacy Meijo University

• ISHIDA Sumio

  Faculty of Pharmacy, Meijo University

• Yonezawa Y

  Faculty Of Pharmacy Meijo University

• Yonezawa Yorinobu

  Faculty Of Pharmaceutical Sciences Meijio University

• Sunada H

  Faculty Of Pharmacy Meijo University

• Sunada Hisakazu

  Fac. Of Pharmacy Meijo Univ.

• Sunada Hisakazu

  Faculty Of Pharmacy Meijo University

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